Kobayashi A, Ide H, Eguchi R, Nakamura T, Hayashi K, Hanyu F
Department of Surgery, Tokyo Women's Medical College, Japan.
Nihon Kyobu Geka Gakkai Zasshi. 1996 Jun;44(6):770-8.
After resection of esophageal carcinoma, pyloroplasty was undergone due to vagal denervation. Especially the ability of oral-taking is related to the return of general societies after operation. This was a randomized study on whether pyloroplasty was effective by functional and nutritional evaluations. From 1992 to 1995, 67 patients with esophageal carcinoma underwent subtotal esophagectomy and reconstruction using a gastric tube. Thirty-four patients were randomized into the pyloroplasty group (P), and 33 into the control group (N). The functional evaluation was done with (1) food-taking scoring (2) A foods with barium granules ejection time (3) a gastric emptying time of 99m Technecium (4) 75 g OGTT. The nutritional evaluation were (1) Rapid Turn-over Protein (RTP) (2) Total Lymphocyte Count (TLC) (3) ONODERA's Prognostic Nutritional Count (PNI) (4) Fluctuation rate of body weight. The elevations were performed 1 and 6 months after operation. Functional evaluation were as follows. (1) Quantity of oral-intake was not significant different between (P) and (N) both improving those quantities in 6 months. Regarding several complaints including in regurgitation, (P) had a few symptoms comparing to (N), almost half of cases complained of some symptoms and did not improving in 6 months. (2) The food ejection time of foods were 19.6 +/- 31.0 min, in (P), 32.9 +/- 37.2 min, in (N), (3) In the Tc gastric emptying time, we calculated as 50% ejecting time and residual rate of 30 min. In 50% ejecting time less than 20 min., (P) shared in 65, 80%, (N) in 39, 40% in 1 and 6 months. (4) In 75 g OGTT there were no significant difference between both groups, though several cases showed the dumping syndrome. In the nutritional evaluation, in RTP, TLC, PNI, and postope, body weight, there were no differences between the two groups. In conclusion, pyloroplasty several symptoms related to oral intake including regurgitation feelings, and in functional evaluation, there shows faster gastric emptying though there were no significant differences in the nutritional phases at 6 months follow-up. The results suggest that this procedure is not essential but it affects to the oral-intake QOL effectively.
食管癌切除术后,由于迷走神经切断术而进行了幽门成形术。尤其是口服能力与术后回归正常社会生活有关。这是一项通过功能和营养评估来研究幽门成形术是否有效的随机研究。1992年至1995年,67例食管癌患者接受了食管次全切除术并用胃管进行重建。34例患者被随机分为幽门成形术组(P),33例进入对照组(N)。功能评估包括:(1)进食评分;(2)含钡颗粒食物的排出时间;(3)99m锝标记的胃排空时间;(4)75g口服葡萄糖耐量试验(OGTT)。营养评估包括:(1)快速周转蛋白(RTP);(2)总淋巴细胞计数(TLC);(3)小野寺预后营养指数(PNI);(4)体重波动率。在术后1个月和6个月进行评估。功能评估结果如下。(1)(P)组和(N)组的口服摄入量在6个月时均有所增加,但两组之间无显著差异。关于包括反流在内的一些不适症状,(P)组的症状比(N)组少,(N)组几乎一半的病例有一些症状且在6个月内未改善。(2)(P)组食物的排出时间为19.6±31.0分钟,(N)组为32.9±37.2分钟。(3)在锝标记的胃排空时间方面,我们计算了50%排出时间和30分钟时的残留率。在50%排出时间小于20分钟的情况中,术后1个月和6个月时(P)组分别占65%、80%,(N)组分别占39%、40%。(4)在75g OGTT中,两组之间无显著差异,尽管有几例出现倾倒综合征。在营养评估中,RTP、TLC、PNI和术后体重方面,两组之间无差异。总之,幽门成形术改善了包括反流感在内的一些与口服摄入相关的症状,在功能评估中,胃排空更快,尽管在6个月随访时营养指标无显著差异。结果表明,该手术并非必需,但能有效影响口服摄入的生活质量。