Suzuki H, Yamaguchi Y, Kimura H, Shiba M, Baba M, Hiroshima K
Department of Surgery, School of Medicine, Chiba University, Japan.
Nihon Kyobu Geka Gakkai Zasshi. 1996 Jun;44(6):864-8.
A case of malignant mediastinal schwannoma associated with von Recklinghausen's disease is reported. A 44-year-old woman was admitted to Chiba University Hospital because of an abnormal shadow on chest X-ray film. CT scan showed a cystic tumor in upper mediastinum and then tumor extirpation was performed. This cystic tumor was related to the sympathetic trunk and 60 x 35 x 33 mm in diameter. Its cut surface showed a thick irregular capsule and multilocular. Microscopic examination disclosed malignant cells with mitosis associated with neurofibroma. An immunohistochemical staining of these malignant cells with anti S-100 protein showed positive reaction. From these findings this tumor was diagnosed as malignant schwannoma. There is no evidence of recurrence two year after the operation. This is the first case of malignant schwannoma with cystic formation in Japan.
报告了一例与冯雷克林霍增氏病相关的恶性纵隔神经鞘瘤。一名44岁女性因胸部X光片出现异常阴影入住千叶大学医院。CT扫描显示上纵隔有一个囊性肿瘤，随后进行了肿瘤切除。这个囊性肿瘤与交感神经干有关，直径为60×35×33毫米。其切面显示有一个厚的不规则包膜且为多房性。显微镜检查发现有恶性细胞伴有与神经纤维瘤相关的有丝分裂。用抗S-100蛋白对这些恶性细胞进行免疫组织化学染色显示阳性反应。根据这些发现，该肿瘤被诊断为恶性神经鞘瘤。术后两年没有复发迹象。这是日本首例有囊性形成的恶性神经鞘瘤。
