Vengerovskiĭ A I, Baturina N O, Chuchalin V S, Saratikov A S
Patol Fiziol Eksp Ter. 1996 Apr-Jun(2):37-9.
In chronic hepatitis induced by long-term CCl4 administration to rats, there was largely an increase in the formation of malonic dialdehyde and Schiff bases, an elevation of glycosaminoglycans and hydroxyproline in collagen fractions, and proliferation of hepatic fibrous tissue. Therapy of CCl4-induced hepatitis with the hepatoprotective antioxidants essentiale and legalone led to decreases in the rate of lipid peroxidation, the production of glycosaminoglycans and collagen and to morphological manifestations of hepatic fibrosis. There was a moderate correlation between the indices of lipid peroxidation and hepatic fibrosis.
长期给大鼠注射四氯化碳诱导慢性肝炎时，丙二醛和席夫碱的形成大量增加，胶原组分中的糖胺聚糖和羟脯氨酸升高，肝纤维组织增生。用具有肝保护作用的抗氧化剂易善力和利加隆治疗四氯化碳诱导的肝炎，可降低脂质过氧化速率、糖胺聚糖和胶原蛋白的产生，并减轻肝纤维化的形态学表现。脂质过氧化指标与肝纤维化之间存在中度相关性。
