Radziszewski A, Surynt M, Kopeć M
Z Poradni internistycznej Szpitala w Dabrowie Tarnowskiej.
Przegl Lek. 1996;53(3):166-7.
Arterial hypertension, especially when co-exists with ischemic heart disease, makes an important clinical and social problem. Necessity to continue a treatment during the whole patients life produces many problems for a patient himself as well as for a physician. Thus, for many years, researches have been carried out to find a medicine that would allow to fully control blood pressure for all day, would have minimal side-effects and could be administered once a day. Beside convertase inhibitors such as Prestarium and Gopten, calcium channel blockers, especially retard verapamil forms like Isoptin SR-240 and SR-120 seem to be the most appropriate medicines, especially when hypertension is accompanied by ischemic heart disease and dysrrythmias. The study was performed in 150 hypertensive patients who were administered Isoptin SR-240 once a day and Isoptin SR-120 twice a day. That dose was sufficient to normalize benign and mild hypertension in most patients. Decreased frequency of dyshrrytmias and chest pain relief were also observed. Trials to increase daily dose up to 360 mg were accompanied by evident side effects such as dizziness and constipations. Much more profitable was to join lower Isoptin dose with convertase inhibitors and diuretics.
动脉高血压，尤其是与缺血性心脏病并存时，成为一个重要的临床和社会问题。患者终身都需要持续治疗，这给患者自身以及医生都带来了诸多问题。因此，多年来人们一直在进行研究，以寻找一种能全天完全控制血压、副作用最小且每日只需服用一次的药物。除了像倍他乐克和洛汀新这样的转换酶抑制剂外，钙通道阻滞剂，尤其是缓释维拉帕米制剂如异搏定SR - 240和SR - 120似乎是最合适的药物，特别是当高血压伴有缺血性心脏病和心律失常时。该研究对150名高血压患者进行，这些患者每日服用一次异搏定SR - 240，每日服用两次异搏定SR - 120。该剂量足以使大多数患者的良性和轻度高血压恢复正常。还观察到心律失常频率降低以及胸痛缓解。将每日剂量增至360毫克的试验伴随着明显的副作用，如头晕和便秘。将较低剂量的异搏定与转换酶抑制剂和利尿剂联合使用则更有益。
