Qian X X, Chen A H, Deng J Y, Tang X M, Liu Y F, Li Z L, Ou S B, Wu Z N, Wang K R
Zhu Jiang Hospital, First Military Medical University, Guangzhou.
Chin Med J (Engl). 1994 Apr;107(4):260-4.
Isoptin SR was used in 65 essential hypertensive patients. 240mg Isoptin SR (German Knoll Pharmaceutical company) per day was used in group A (35 cases) for 6 weeks, and in group B (30 cases) for 24 weeks, BP in group A and B decreased obviously in the first and second week after treatment. Marked effective rate and total effective rate were 65.7% and 74.3% respectively in group A, and 70.0% and 83.3% in group B. There were no significant changes of HR in group A before and after treatment while there was a decrease of HR in group B (P < 0.001). Left atrium (LA) decreased after 6 weeks in group A with an obvious increase of E/A ratio. There was significant decrease in LA, increase in E/A ratio, regression of IVS, LVPW and LVMI, but no changes in SV, CO, LVEF after 24 weeks of treatment of Isoptin SR in group B. E/A ratio was very sensitive and occurred earliest both in group A and group B. Side effects such as headache, dizziness, constipation, insomnia, peripheral oedema, sinus bradycardia occurred mainly in the first week of treatment. These symptoms disappeared gradually in the course of continued administration of Isoptin SR.
65例原发性高血压患者使用了缓释异搏定。A组（35例）每天服用240mg缓释异搏定（德国克诺尔制药公司生产），疗程6周；B组（30例）每天服用240mg缓释异搏定，疗程24周。治疗后第1周和第2周，A组和B组血压均明显下降。A组显效率和总有效率分别为65.7%和74.3%，B组分别为70.0%和83.3%。A组治疗前后心率无明显变化，而B组心率下降（P<0.001）。A组治疗6周后左心房（LA）减小，E/A比值明显升高。B组服用缓释异搏定24周后，LA明显减小，E/A比值升高，室间隔（IVS）、左室后壁（LVPW）厚度及左室质量指数（LVMI）均减小，而每搏输出量（SV）、心输出量（CO）、左室射血分数（LVEF）无变化。A组和B组中E/A比值均最为敏感且出现最早。副作用如头痛、头晕、便秘、失眠、外周水肿、窦性心动过缓主要出现在治疗第1周。在继续服用缓释异搏定的过程中，这些症状逐渐消失。
