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[氟哌啶醇诱导的僵住状态的巩固与再现]

[The consolidation and reproduction of a state of haloperidol-induced catalepsy].

作者信息

Bazian A S, Getsova V M, Orlova N V

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1996 May-Jun;46(3):571-7.

PMID:8755063
Abstract

Catalepsy induced by a single intraperitoneal injection of haloperidol (2.5 mg/kg) was consolidated and without additional influences and retained within 2 week (being tested on the 2nd, 7th, and 14th days after injection). Enhancement of catalepsy retrieval was observed during testing of the same animals on the 14th day as compared with the 7th day. Maximal catalepsy expression was reached after 2 hours of testing procedure which points to the existence of the mechanism of autoenhancement of retrieval which is probably underlain by the automodulation of the long-lasting modulatory DA receptors. The retrieval of catalepsy is suggested to be induced by a situational conditioned stimulus, since on the 2nd, 7th and 14th days it may be reproduced without repeated haloperidol injection only in the testing box.

摘要

单次腹腔注射氟哌啶醇(2.5毫克/千克)诱导的僵住症在2周内得到巩固且无额外影响(在注射后的第2、7和14天进行测试)。与第7天相比,在第14天对相同动物进行测试时观察到僵住症恢复增强。测试程序进行2小时后达到最大僵住症表现,这表明存在恢复自动增强机制,其可能由持久调节性多巴胺受体的自动调节为基础。僵住症的恢复被认为是由情境条件刺激诱导的,因为在第2、7和14天,仅在测试箱中无需重复注射氟哌啶醇即可再现。

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