整合子In0、In2和In5是有缺陷的转座子衍生物。
The integrons In0, In2, and In5 are defective transposon derivatives.
作者信息
Brown H J, Stokes H W, Hall R M
机构信息
School of Biological Sciences, Macquarie University, New South Wales, Australia.
出版信息
J Bacteriol. 1996 Aug;178(15):4429-37. doi: 10.1128/jb.178.15.4429-4437.1996.
Abstract
The class 1 integrons In0, In2, and In5, found in different locations in pVS1, Tn21, and pSCH884, have closely related structures. All three integrons contain an insertion sequence, IS1326, that is a new member of the IS21 family. IS1326 has caused deletions of adjacent 3'-conserved segment and transposition module sequences, and all three integrons retain a complete copy of only one of four genes required for transposition of related transposons and are thus defective transposon derivatives. In2 contains an additional insertion sequence, IS1353, located within IS1326. IS1353 is a member of the IS3 family and appears to have been acquired after the integron was inserted into an ancestral mercury resistance transposon to create the ancestor of Tn21 and several other transposons that are close relatives of Tn21.
摘要
在pVS1、Tn21和pSCH884的不同位置发现的1类整合子In0、In2和In5具有密切相关的结构。所有这三个整合子都包含一个插入序列IS1326，它是IS21家族的一个新成员。IS1326导致了相邻3'保守区段和转座模块序列的缺失，并且所有这三个整合子仅保留了相关转座子转座所需的四个基因中的一个的完整拷贝，因此是有缺陷的转座子衍生物。In2包含另一个插入序列IS1353，位于IS1326内。IS1353是IS3家族的成员，似乎是在整合子插入到一个祖先汞抗性转座子中以创建Tn21的祖先以及其他几个与Tn21关系密切的转座子之后获得的。
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