Carr E A, Spier S J, Kortz G D, Hoffman E P
Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis 95616, USA.
J Am Vet Med Assoc. 1996 Aug 15;209(4):798-803.
Evaluate histories, clinical signs, and laboratory data of 69 horses homozygous by DNA testing for hyperkalemic periodic paralysis (HPP).
Cohort study.
69 of 189 horses testing homozygous for HPP between October 1992 and November 1994.
Questionnaires addressing signalment, training regimes, medical history, and current status of affected horses were sent to owners, trainers, or attending veterinarians. Data from completed questionnaires were tabulated and evaluated, using descriptive statistics.
Sixty-nine (37%) of 189 questionnaires were completed and returned. Clinical episodes of muscle weakness or paralysis varied in severity and frequency from mild muscle fasciculations to recumbency and death. Sixty-three of 68 HPP-affected horses were reported to have had stridor associated with exercise, excitement, stress, or episodes of muscle paralysis. Common endoscopic findings in affected horses included pharyngeal collapse, pharyngeal edema, laryngopalatal dislocation, and laryngeal paralysis. Twelve of 27 horses receiving acetazolamide had decreases in stridor while receiving medication.
Most horses testing homozygous for HPP had clinical signs associated with pharyngeal and laryngeal dysfunction. Hyperkalemic periodic paralysis should be included on a differential list for horses examined for signs of laryngeal or pharyngeal dysfunction or stridor. Treatment with acetazolamide may help to control respiratory tract signs associated with this disease.
评估69匹经DNA检测确诊为高钾性周期性麻痹（HPP）纯合子的马匹的病史、临床症状和实验室数据。
队列研究。
1992年10月至1994年11月间189匹检测为HPP纯合子的马匹中的69匹。
向马匹所有者、训练师或主治兽医发送了关于马匹特征、训练方式、病史和患病马匹当前状况的问卷。对已完成问卷的数据进行列表并使用描述性统计进行评估。
189份问卷中有69份（37%）填写并返回。肌肉无力或麻痹的临床发作严重程度和频率各不相同，从轻度肌肉震颤到卧地不起甚至死亡。68匹受HPP影响的马匹中有63匹据报告在运动、兴奋、应激或肌肉麻痹发作时出现喘鸣。患病马匹常见的内镜检查结果包括咽塌陷、咽水肿、喉腭脱位和喉麻痹。27匹接受乙酰唑胺治疗的马匹中有12匹在用药期间喘鸣减轻。
大多数检测为HPP纯合子的马匹有与咽和喉功能障碍相关的临床症状。对于检查有喉或咽功能障碍或喘鸣迹象的马匹，鉴别诊断列表中应包括高钾性周期性麻痹。乙酰唑胺治疗可能有助于控制与该病相关的呼吸道症状。
