Fan Zaifeng, Smith Peter A, Harris Gerald F, Rauch Frank, Bajorunaite Ruta
Orthopaedic and Rehabilitation Engineering Center, Marquette University, Milwaukee, Wisconsin 53201, USA.
Connect Tissue Res. 2007;48(2):70-5. doi: 10.1080/03008200601090949.
Nanoindentation was used to compare the intrinsic mechanical properties of bone tissue (iliac crest biopsy) from children with type III and type IV osteogenesis imperfecta (OI). Young's modulus and hardness values were not significantly different between the two clinical severity groups on either cortical or trabecular measurement. In comparing the ratio of modulus over hardness (E/H) between OI type III and IV. The type III bone showed a marginally significant decrease for cortical bone and significant decrease for trabecular bone, which indicated that the OI type III bone was more brittle than OI type IV bone at the tissue level. In addition, nanoindentation measurements of the bone tissue harvested at femur/tibia from the same patients were compared with the results from the iliac crest biopsy. Young's modulus and hardness values were not significantly different between the two anatomic locations in either cortical or trabecular measurements. The ratio of E/H was not significantly different between the two groups. Results indicate that intrinsic modulus, hardness, and indentation deformation pattern (E/H) of OI bone tissues are not significantly different at long bone (midshaft of femur/tibia) and iliac crest. We observed that age (1.9 to 13.2 years) did not influence OI bone tissue intrinsic mechanical properties.
采用纳米压痕技术比较III型和IV型成骨不全症（OI）患儿骨组织（髂嵴活检）的固有力学性能。在皮质骨或小梁骨测量中，两个临床严重程度组之间的杨氏模量和硬度值无显著差异。比较III型和IV型OI之间的模量与硬度之比（E/H）。III型骨的皮质骨E/H比值略有显著下降，小梁骨则显著下降，这表明在组织水平上，III型OI骨比IV型OI骨更脆。此外，将同一患者股骨/胫骨采集的骨组织的纳米压痕测量结果与髂嵴活检结果进行比较。在皮质骨或小梁骨测量中，两个解剖位置之间的杨氏模量和硬度值无显著差异。两组之间的E/H比值无显著差异。结果表明，OI骨组织在长骨（股骨/胫骨骨干中部）和髂嵴处的固有模量、硬度和压痕变形模式（E/H）无显著差异。我们观察到年龄（1.9至13.2岁）不影响OI骨组织的固有力学性能。
