Pintér E, Kriván G
Központi Klinikai Laboratórium, Fóvárosi Szent László Kórház, Budapest.
Orv Hetil. 1996 Jun 9;137(23):1259-62.
Serum quantitative C-reactive protein concentrations were measured in 16 bone marrow transplanted children at 202 occasions during and after the transplant period. Serum C-reactive protein concentrations were moderately increased in patients with viral and protozoon infections (5-67 mg/l). High values were measured in patients with bacterial and fungal infections. The C-reactive protein level was between 15-102 mg/l in Coag. neg. Staphylococcus sepsis, and 160-178 mg/l in Pseudomonas aeruginosa infection, when blood cultures were positive. Values of 154-358 mg/l was found with Candida sepsis. C-reactive protein levels were 10-17 mg/l in 7 acute GvHD episodes, only one of the patients had high level (325 mg/l) in GvHD. In these cases the condition was very severe and affected the total surface of the skin and the gastrointestinal tract also. C-reactive protein becomes a valuable aid as laboratory parameter in the diagnosis of bone marrow transplant recipients with suspected bacterial infection and in monitoring of therapeutic efficiency.
在16名接受骨髓移植的儿童移植期间及移植后的202个时间点测量了血清C反应蛋白定量浓度。病毒和原生动物感染患者的血清C反应蛋白浓度中度升高（5 - 67毫克/升）。细菌和真菌感染患者的测量值较高。凝固酶阴性葡萄球菌败血症患者的C反应蛋白水平在15 - 102毫克/升之间，铜绿假单胞菌感染且血培养阳性时，C反应蛋白水平在160 - 178毫克/升之间。念珠菌败血症患者的C反应蛋白值为154 - 358毫克/升。7例急性移植物抗宿主病发作时C反应蛋白水平为10 - 17毫克/升，只有1例患者在移植物抗宿主病时C反应蛋白水平较高（325毫克/升）。在这些病例中，病情非常严重，皮肤和胃肠道全层均受累。C反应蛋白作为实验室参数，在诊断疑似细菌感染的骨髓移植受者及监测治疗效果方面成为一项有价值的辅助指标。
