塞伯罗斯是一种在施佩曼组织者的前端内胚层中表达的诱导头部的分泌因子。
Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer.
作者信息
Bouwmeester T, Kim S, Sasai Y, Lu B, De Robertis E M
机构信息
Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, 90095-1737, USA.
出版信息
Nature. 1996 Aug 15;382(6592):595-601. doi: 10.1038/382595a0.
An abundant cDNA enriched in Spemann's organizer, cerberus, was isolated by differential screening. It encodes a secreted protein that is expressed in the anterior endomesoderm. Microinjection of cerberus mRNA into Xenopus embryos induces ectopic heads, and duplicated hearts and livers. The results suggest a role for a molecule expressed in the anterior endoderm in the induction of head structures in the vertebrate embryo.
通过差异筛选分离出了一种在施佩曼组织者中富集的丰富cDNA，即头蛋白。它编码一种在前肠内胚层中表达的分泌蛋白。将头蛋白mRNA显微注射到非洲爪蟾胚胎中会诱导异位头部以及心脏和肝脏的复制。这些结果表明，前内胚层中表达的一种分子在脊椎动物胚胎头部结构的诱导中发挥作用。
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