Nelson R P, DiNicolo R, Fernández-Caldas E, Seleznick M J, Lockey R F, Good R A
University of South Florida College of Medicine/All Children's Hospital, Tampa, USA.
J Allergy Clin Immunol. 1996 Aug;98(2):258-63. doi: 10.1016/s0091-6749(96)70148-3.
Sensitization to allergens has been shown to be a risk factor for adults with acute asthma first seen in the emergency department.
The purpose of this study was to evaluate the prevalence of specific IgE to common aeroallergens in children with asthma first seen in the emergency department and in control subjects.
Fifty-four children, aged 3 to 16 years (mean age, 8.34 years) who visited the emergency department for treatment of acute bronchospasm or other illness, were evaluated. Specific IgE to seven common aeroallergens and four common storage mites was determined. Group I consisted of 29 patients who had acute bronchospasm and histories of recurrent asthma. Group II consisted of 25 control subjects who had no clinical history of atopic disease. Group I and II were compared for differences in the prevalence of positive RAST responses to the 11 allergens tested. Dust samples were collected from 17 homes of subjects in group I and from 13 homes of subjects in group II and were analyzed for levels of Der p 1 and Der f 1.
Statistically significant differences in the prevalence of positive RAST results between groups I and II were found in response to: Dermatophagoides pteronyssinus, 89.6% versus 36% (p = 0.0001); Blattella germanica, 45.8% versus 9.5% (p = 0.018); Alternaria tenuis, 44.8% versus 4% (p = 0.001); and the storage mites Aleuroglyphus ovatus, 39.2% versus 4% (p = 0.002); Blomia tropicalis, 42.8% versus 0% (p = 0.0002); Chortoglyphus arcuatus, 46.4% versus 0% (p = 0.0001); and Lepidoglyphus destructor, 32.1% versus 0% (p = 0.0019). Mean specific IgE levels, expressed as percent of the total counts bound, were significantly higher in group I compared with group II only in response to D. pteronyssinus, 21.9% versus 2.1% (mean percent of total counts bound) (p = 0.0001). Analysis of dust samples revealed no significant differences between the two groups, except for a higher concentration of Der f 1 in the sofas of subjects in group II.
Sensitization to D. pteronyssinus, storage mites, and, to a lesser extent, to A. tenuis and B. germanica is associated with acute childhood asthma that requires emergency treatment in Florida.
对过敏原致敏已被证明是在急诊科初诊的成年急性哮喘患者的一个风险因素。
本研究的目的是评估在急诊科初诊的哮喘儿童及对照受试者中，对常见气传过敏原特异性IgE的患病率。
对54名年龄在3至16岁（平均年龄8.34岁）因急性支气管痉挛或其他疾病到急诊科就诊的儿童进行评估。测定了对7种常见气传过敏原和4种常见仓储螨的特异性IgE。第一组由29例有急性支气管痉挛和复发性哮喘病史的患者组成。第二组由25名无特应性疾病临床病史的对照受试者组成。比较第一组和第二组对11种测试过敏原的RAST阳性反应患病率的差异。从第一组受试者的17个家庭和第二组受试者的13个家庭收集灰尘样本，并分析其中Der p 1和Der f 1的水平。
在第一组和第二组之间，RAST阳性结果的患病率在以下方面存在统计学显著差异：屋尘螨，89.6%对36%（p = 0.0001）；德国小蠊，45.8%对9.5%（p = 0.018）；链格孢，44.8%对4%（p = 0.001）；以及仓储螨椭圆食粉螨，39.2%对4%（p = 0.002）；热带无爪螨，42.8%对0%（p = 0.0002）；弯尾蚍蜉螨，46.4%对0%（p = 0.0001）；和柏氏禽刺螨，32.1%对0%（p = 0.0019）。仅在对屋尘螨的反应中，以结合的总计数百分比表示的平均特异性IgE水平，第一组显著高于第二组，分别为21.9%对2.1%（结合的总计数平均百分比）（p = 0.0001）。灰尘样本分析显示两组之间无显著差异，只是第二组受试者沙发中Der f 1的浓度较高。
在佛罗里达州，对屋尘螨、仓储螨以及在较小程度上对链格孢和德国小蠊致敏与需要急诊治疗的儿童急性哮喘相关。
