Warner A, Boström S, Munir A K, Möller C, Schou C, Kjellman N I
Department of Paediatrics, Helsingborg Hospital, Sweden.
Allergy. 1998 Jul;53(7):698-704. doi: 10.1111/j.1398-9995.1998.tb03956.x.
The major allergen of Dermatophagoides microceras, Der m 1, as well as the allergens of D. pteronyssinus and D. farinae, Der p 1 and Der f 1, were analyzed in the homes of 111 asthmatic children in three climatic regions in Sweden. The numbers and species of mites were determined by microscopy, and circulating IgE antibodies against mites were measured. Der f 1 was the predominant house-dust-mite (HDM) allergen, Der p 1 the least often found, and Der m 1 represented 31% of the allergen load. However, in the Linköping area, Der m 1 was the major HDM allergen (58%). Mite counts and allergen levels correlated well. Current exposure to HDM allergens at home was associated with the serum IgE antibody response to HDM in the children with no threshold level. Of the children with IgE antibodies against HDM, 67% reacted to all three mites. Mite sensitization rates were marginally increased (7%) by the addition of IgE analysis of D. microceras to the routine analysis of IgE antibodies against D. pteronyssinus and D. farinae. Thus, Der m 1 may be an important HDM allergen and should be considered when HDM exposure data are assessed in areas with a climate like that of Sweden.
对瑞典三个气候区域111名哮喘儿童家中的微小屋尘螨主要变应原Der m 1以及粉尘螨和户尘螨变应原Der p 1和Der f 1进行了分析。通过显微镜检查确定螨的数量和种类，并检测针对螨的循环IgE抗体。Der f 1是主要的屋尘螨（HDM）变应原，Der p 1最少见，Der m 1占变应原负荷的31%。然而，在林雪平地区，Der m 1是主要的HDM变应原（58%）。螨计数与变应原水平相关性良好。家中当前对HDM变应原的暴露与儿童血清中对HDM的IgE抗体反应相关，且无阈值水平。在对HDM有IgE抗体的儿童中，67%对所有三种螨均有反应。在针对粉尘螨和户尘螨的IgE抗体常规分析中增加对微小屋尘螨的IgE分析后，螨致敏率略有增加（7%）。因此，Der m 1可能是一种重要的HDM变应原，在评估瑞典这样气候地区的HDM暴露数据时应予以考虑。
