Christiansen S C, Martin S B, Schleicher N C, Koziol J A, Hamilton R G, Zuraw B L
Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA, USA.
J Allergy Clin Immunol. 1996 Aug;98(2):288-94. doi: 10.1016/s0091-6749(96)70152-5.
Environmental living conditions co-sorting with economic status may influence the disease morbidity rate of childhood asthma in ethnic minority urban poor populations.
This study was carried out to assess exposure and sensitization to environmental allergens in southeast San Diego children with current asthma-related symptoms and to determine the utility of environmental control measures.
Children, 9 to 12 years old, with current asthma-related symptoms were identified and enrolled at four school sites. Skin prick testing with aeroallergens was performed, and allergen in collected dust (from mattresses, pillows, and bedroom carpets) was quantified by enzyme immunoassay. Environmental control instruction and products were provided.
Of 41 subjects who underwent skin testing, 51.2% were reactive to environmental allergens (39% to mite, 22% to cockroach, and 9.8% to cat). Mean allergen levels for sensitized subjects were: Der p 1 (11 subjects), 18,722 ng/gm dust; Der f 1 (8 subjects), 5345 ng/gm dust; Fel d 1 (3 subjects), 214 ng/gm dust; Bla 1 (8 subjects), 7.15 U/gm dust; and Bla 2 (8 subjects) 7.13 U/gm dust. Environmental allergen exposure levels were not significantly different between sensitized and nonsensitized subjects. Environmental control measures for mite exposure were completed in six homes of sensitized subjects. One month after treatment, allergen levels fell 91.2% for Der p 1, 98.9% for Der f 1, and 88.2% for Fel d 1. One year after treatment, mite and cat allergen levels remained low. Environmental control had no consistent impact on cockroach allergen levels.
Environmental allergen sensitization and exposure may be cofactors contributing to increased disease severity in urban poor populations.
与经济状况共同分类的环境生活条件可能会影响少数民族城市贫困人口中儿童哮喘的发病率。
本研究旨在评估圣地亚哥东南部目前有哮喘相关症状的儿童对环境过敏原的暴露和致敏情况，并确定环境控制措施的效用。
识别并招募了4个学校地点的9至12岁有目前哮喘相关症状的儿童。进行了空气过敏原皮肤点刺试验，并通过酶免疫测定法定量收集的灰尘（来自床垫、枕头和卧室地毯）中的过敏原。提供了环境控制指导和产品。
在接受皮肤测试的41名受试者中，51.2%对环境过敏原呈反应性（对螨虫反应性为39%，对蟑螂为22%，对猫为9.8%）。致敏受试者的平均过敏原水平为：Der p 1（11名受试者），18,722 ng/gm灰尘；Der f 1（8名受试者），5345 ng/gm灰尘；Fel d 1（3名受试者），214 ng/gm灰尘；Bla 1（8名受试者），7.15 U/gm灰尘；以及Bla 2（8名受试者）7.13 U/gm灰尘。致敏和未致敏受试者之间的环境过敏原暴露水平无显著差异。在6名致敏受试者的家中完成了针对螨虫暴露的环境控制措施。治疗1个月后，Der p 1的过敏原水平下降了91.2%，Der f 1下降了98.9%，Fel d 1下降了88.2%。治疗1年后，螨虫和猫过敏原水平仍然较低。环境控制对蟑螂过敏原水平没有一致的影响。
环境过敏原致敏和暴露可能是导致城市贫困人口疾病严重程度增加的共同因素。
