Hunninghake Gary M, Weiss Scott T, Celedón Juan C
Channing Laboratory, Dept. of Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA 02115, USA.
Am J Respir Crit Care Med. 2006 Jan 15;173(2):143-63. doi: 10.1164/rccm.200508-1232SO. Epub 2005 Oct 6.
Hispanic individuals trace their ancestry to countries that were previously under Spanish rule, including Mexico, large parts of Central and South America, and some Caribbean islands. Most--but not all--Hispanics have variable proportions of European, Amerindian, and African ancestry. Hispanics are diverse with regard to many factors, including racial ancestry, country of origin, area of residence, socioeconomic status, education, and access to health care. Recent findings suggest that there is marked variation in the prevalence, morbidity, and mortality of asthma in Hispanics in the United States and in Hispanic America. The reasons for differences in asthma and asthma morbidity among and within Hispanic subgroups are poorly understood but are likely due to the interaction between yet-unidentified genetic variants and other factors, including environmental tobacco smoke exposure, obesity, allergen exposure, and availability of health care. Barriers to optimal management of asthma in Hispanics in the United States and in Hispanic America include inadequate access to health care, suboptimal use of antiinflammatory medications, and lack of reference values for spirometric measures of lung function in many subgroups (e.g., Puerto Ricans). Future studies of asthma in Hispanics should include large samples of subgroups that are well characterized with regard to self-reported ethnicity, country of origin, place of birth, area of residence, and indicators of socioeconomic status. Because Hispanics are disproportionately represented among the poor in the United States, implementation of adequate access to health care and social reforms (e.g., improving housing conditions) would likely have a major impact on reducing asthma morbidity in this population.
西班牙裔个体的祖先来自以前受西班牙统治的国家,包括墨西哥、中美洲和南美洲的大部分地区以及一些加勒比岛屿。大多数(但并非全部)西班牙裔有着不同比例的欧洲、美洲印第安人和非洲血统。西班牙裔在许多因素方面存在差异,包括种族血统、原籍国、居住地区、社会经济地位、教育程度以及获得医疗保健的机会。最近的研究结果表明,在美国的西班牙裔和拉丁美洲的西班牙裔中,哮喘的患病率、发病率和死亡率存在显著差异。西班牙裔亚组之间以及亚组内部哮喘及哮喘发病率存在差异的原因尚不清楚,但可能是由于尚未确定的基因变异与其他因素之间的相互作用,这些因素包括环境烟草烟雾暴露、肥胖、过敏原暴露以及医疗保健的可及性。在美国的西班牙裔和拉丁美洲的西班牙裔中,哮喘最佳管理的障碍包括获得医疗保健的机会不足、抗炎药物使用不当以及许多亚组(如波多黎各人)缺乏肺功能肺活量测定指标的参考值。未来对西班牙裔哮喘的研究应纳入大量亚组样本,这些样本应在自我报告的种族、原籍国、出生地、居住地区和社会经济地位指标方面有充分的特征描述。由于在美国贫困人口中西班牙裔所占比例过高,实施充足的医疗保健可及性和社会改革(如改善住房条件)可能会对降低该人群的哮喘发病率产生重大影响。