Khoddami M, Bedard Y C, Bell R S, Kandel R A
Department of Pathology, Mount Sinai Hospital and the University of Toronto, Ontario, Canada.
Arch Pathol Lab Med. 1996 Jul;120(7):671-5.
To report seven cases of intraosseous leiomyosarcoma and compare them with the cases in the literature.
Retrospective review of histologic, immunohistochemical, and ultrastructural features. Tumors were examined immunohistochemically for proliferative activity and p53 protein accumulation.
Mount Sinai Hospital, University of Toronto, Ontario, Canada.
The histologic grade of the tumors ranged from I to III. All tumors showed vimentin and muscle-specific actin immunoreactivity and smooth muscle differentiation ultrastructurally. Proliferative activity was demonstrated immunohistochemically in five of the seven cases. Only one tumor showed p53 protein accumulation.
Primary leiomyosarcoma of bone is an aggressive tumor with light microscopic, ultrastructural, and immunohistochemical features similar to leiomyosarcoma of soft tissue. The proliferative activity of these tumors does not appear to correlate with the histologic grade. p53 protein accumulation as detected by immunostaining is not common in these tumors.
报告7例骨内平滑肌肉瘤病例，并与文献中的病例进行比较。
对组织学、免疫组织化学和超微结构特征进行回顾性分析。对肿瘤进行免疫组织化学检查以评估增殖活性和p53蛋白积累情况。
加拿大多伦多大学西奈山医院。
肿瘤的组织学分级为I至III级。所有肿瘤均显示波形蛋白和肌肉特异性肌动蛋白免疫反应阳性，超微结构显示平滑肌分化。7例中有5例通过免疫组织化学显示有增殖活性。只有1例肿瘤显示p53蛋白积累。
原发性骨平滑肌肉瘤是一种侵袭性肿瘤，其光镜、超微结构和免疫组织化学特征与软组织平滑肌肉瘤相似。这些肿瘤的增殖活性似乎与组织学分级无关。免疫染色检测到的p53蛋白积累在这些肿瘤中并不常见。
