Kimura F, Nakamura Y, Sato K, Wakimoto N, Kato T, Tahara T, Yamada M, Nagata N, Motoyoshi K
Third Department of Internal Medicine, National Defence Medical College, Saitama, Japan.
Br J Haematol. 1996 Jul;94(1):171-4. doi: 10.1046/j.1365-2141.1996.d01-1783.x.
The serial change of various cytokines in the serum from a patient with cyclic thrombocytopenia is described. Interleukin 7, stem cell factor, and transforming growth factor beta 1 synchronized with the platelet count, and there was a significant positive correlation between the three cytokines and the platelet count. Levels of macrophage colony-stimulating factor, thrombopoietin, platelet-associated IgG and erythropoietin changed reciprocally with the platelet count, and there was a significant negative correlation between the platelet count and these cytokines except erythropoietin. No cyclic change was observed in IL-3, IL-6, IL-11, granulocyte-macrophage colony-stimulating factor, or leukaemia inhibitory factor. These observations suggest that this disease involves two cyclic changes: megakaryocytopoiesis and platelet destruction, in both of which the cytokines play an important role.
描述了一名周期性血小板减少症患者血清中各种细胞因子的系列变化。白细胞介素7、干细胞因子和转化生长因子β1与血小板计数同步，且这三种细胞因子与血小板计数之间存在显著正相关。巨噬细胞集落刺激因子、血小板生成素、血小板相关IgG和促红细胞生成素水平与血小板计数呈反向变化，除促红细胞生成素外，血小板计数与这些细胞因子之间存在显著负相关。在IL-3、IL-6、IL-11、粒细胞-巨噬细胞集落刺激因子或白血病抑制因子中未观察到周期性变化。这些观察结果表明，该疾病涉及两种周期性变化：巨核细胞生成和血小板破坏，细胞因子在这两种变化中均起重要作用。
