Wu G, Danska J S, Guidos C J
Wellesley Hospital Research Institute, University of Toronto, Toronto, Ontario, Canada.
Int Immunol. 1996 Jul;8(7):1159-64. doi: 10.1093/intimm/8.7.1159.
The src family tyrosine kinase, Lck, transduces signals from the pre-TCR complex which regulate the development and expansion of CD4/CD8 double-positive (DP) thymocytes from CD25(+) CD4/CD8 double-negative progenitors. We and others have recently shown that sublethal gamma-irradiation bypasses the need for TCRbeta expression to promote the development and expansion of DP thymocytes in scid or recombinase-activating gene (RAG)-deficient mice. Here we demonstrate that gamma-irradiation activates an Lck-dependent signaling process in immature thymocytes similar to that initiated physiologically by the pre-TCR complex.
Src家族酪氨酸激酶Lck转导来自前TCR复合体的信号，这些信号调节CD25(+) CD4/CD8双阴性祖细胞来源的CD4/CD8双阳性（DP）胸腺细胞的发育和扩增。我们和其他人最近发现，亚致死剂量的γ射线照射可绕过对TCRβ表达的需求，从而促进scid或重组酶激活基因（RAG）缺陷小鼠中DP胸腺细胞的发育和扩增。在这里，我们证明γ射线照射可激活未成熟胸腺细胞中依赖Lck的信号传导过程，该过程类似于前TCR复合体在生理上启动的过程。
