在自然界中，丙型流感病毒毒株之间频繁发生基因重配。

Frequent occurrence of genetic reassortment between influenza C virus strains in nature.

作者信息

Peng G, Hongo S, Kimura H, Muraki Y, Sugawara K, Kitame F, Numazaki Y, Suzuki H, Nakamura K

机构信息

Department of Bacteriology, Yamagata University School of Medicine, Japan.

出版信息

J Gen Virol. 1996 Jul;77 ( Pt 7):1489-92. doi: 10.1099/0022-1317-77-7-1489.

DOI:10.1099/0022-1317-77-7-1489

PMID:8757991

Abstract

Previous studies of the haemagglutinin-esterase (HE) genes of various influenza C isolates suggested the existence of three distinct virus lineages (C/Yamagata/26/81-, C/Aichi/1/81- and C/Mississippi/80-related lineages) in Japan in the 1980s. Here we analysed the genetic properties of three strains (C/Yamagata/5/92, C/Miyagi/3/93 and C/Miyagi/4/93) isolated in Yamagata and Sendai Cities, Japan, in 1992/1993. Comparison of total or partial nucleotide sequences of the seven RNA segments of C/Yamagata/5/92 with those of 11 previous isolates suggested that the 1992 strain is a reassortant which inherited HE, P3, NP and M genes from a C/Mississippi/80-like virus and PB2, PB1 and NS genes from a C/pig/Beijing/115/81-like virus. Furthermore, it became evident that at least two (C/England/83 and C/Yamagata/9/88) of the 11 reference strains are also reassortants.

摘要

以往对各种丙型流感病毒分离株血凝素酯酶（HE）基因的研究表明，20世纪80年代日本存在三种不同的病毒谱系（C/山形/26/81谱系、C/爱知/1/81谱系和C/密西西比/80相关谱系）。在此，我们分析了1992年/1993年在日本山形市和仙台市分离出的三株病毒（C/山形/5/92、C/宫城/3/93和C/宫城/4/93）的遗传特性。将C/山形/5/92的七个RNA片段的全部或部分核苷酸序列与之前的11株分离株进行比较，结果表明，1992年的毒株是一种重组体，它从一株类似C/密西西比/80的病毒中继承了HE、P3、NP和M基因，从一株类似C/猪/北京/115/81的病毒中继承了PB2、PB1和NS基因。此外，很明显，11株参考毒株中至少有两株（C/英格兰/83和C/山形/9/88）也是重组体。