Lee S S, Lo Y C, Wong K H
AIDS Unit, Department of Health, Hong Kong.
Chin Med J (Engl). 1996 Jan;109(1):70-6.
To study the clinical and epidemiological characteristics of the first 100 reported AIDS cases in Hong Kong.
The case records of the first 100 AIDS cases reported to the Department of Health were retrieved. An analysis was made on their demographic data, clinical and immunologic profile, treatment received as well as mortality.
The AIDS patients were reported over a ten-year period, from February 1985 to March 1994. The majority of them were male, Chinese and between the age of 20 and 49. More than 80% acquired HIV via sexual contact. The most common primary AIDS- defining illness was Pneumocystis carinii pneumonia (PCP), which occurred in 46 patients. Eight episodes of Penicillium marneffei infection have been recorded. Fifty-nine patients have received antiretroviral therapy whereas PCP prophylaxis was given to 47 patients. The mean CD4 count at HIV and AIDS diagnosis was 394/microliters and 121 /microliters respectively. Sixty-seven patients were known to have died at the time of the analysis. PCP was the most common cause of death, accounting for over one-fifth of the cases. The median survival after AIDS diagnosis was less than 2 months for cases reported in 1985-1987 and over 15 months for those of 1990-1991.
Pneumocystis carinii pneumonia was the most common initial AIDS-defining disease and cause of death in Hong Kong. Survival of the patients has gradually improved over the past few years.
研究香港报告的首批100例艾滋病病例的临床和流行病学特征。
检索向卫生署报告的首批100例艾滋病病例的病历。对其人口统计学数据、临床和免疫学特征、接受的治疗以及死亡率进行分析。
这些艾滋病患者报告于1985年2月至1994年3月的十年期间。他们大多数为男性、中国人，年龄在20至49岁之间。超过80% 通过性接触感染艾滋病毒。最常见的艾滋病界定原发性疾病是卡氏肺孢子虫肺炎（PCP），有46例患者发生该疾病。记录到8例马尔尼菲青霉感染。59例患者接受了抗逆转录病毒治疗，47例患者接受了PCP预防治疗。艾滋病毒和艾滋病诊断时的平均CD4细胞计数分别为394/微升和121/微升。分析时已知67例患者死亡。PCP是最常见的死亡原因，占病例的五分之一以上。1985 - 1987年报告病例的艾滋病诊断后中位生存期不到2个月，1990 - 1991年报告病例的中位生存期超过15个月。
卡氏肺孢子虫肺炎是香港最常见的初始艾滋病界定疾病和死亡原因。过去几年患者的生存期逐渐改善。
