哌拉西林、头孢他啶、头孢吡肟和头孢匹罗对具有内在替卡西林耐药性的铜绿假单胞菌菌株的活性。
Activities of piperacillin, ceftazidime, cefepime and cefpirome against Pseudomonas aeruginosa strains with intrinsic ticarcillin resistance.
作者信息
Bert F, Setbon P G, Lambert-Zechovsky N, Branger C
机构信息
Service de Microbiologie, Hôpital Beaujon, Clichy, France.
出版信息
Chemotherapy. 1996 Nov-Dec;42(6):426-31. doi: 10.1159/000239475.
The in vitro activities of cefepime and cefpirome against 44 intrinsically ticarcillin-resistant strains of Pseudomonas aeruginosa were compared to their activities against 20 ticarcillin-susceptible strains by MIC determination and the disk test. Time-killing curves were constructed for piperacillin, ceftazidime, cefepime and cefpirome against two susceptible and two resistant strains. The activities of cefepime and cefpirome against the resistant strains were impaired, and most of the strains were of intermediate sensitivity to these agents. The time-killing curves of the four beta-lactams were similar, with a modest decline in viable cell counts over the first 6 h followed by regrowth. There was no difference between the susceptible and resistant strains.
通过最小抑菌浓度（MIC）测定和纸片扩散法，比较了头孢吡肟和头孢匹罗对44株天然对替卡西林耐药的铜绿假单胞菌的体外活性及其对20株对替卡西林敏感菌株的活性。构建了哌拉西林、头孢他啶、头孢吡肟和头孢匹罗对两株敏感菌株和两株耐药菌株的时间杀菌曲线。头孢吡肟和头孢匹罗对耐药菌株的活性受损，大多数菌株对这些药物呈中度敏感。四种β-内酰胺类药物的时间杀菌曲线相似，在前6小时活菌数适度下降，随后再生长。敏感菌株和耐药菌株之间没有差异。
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