Zhang L, Lin J, Cai L
Capital Institute of Pediatrics, Beijing.
Zhonghua Fu Chan Ke Za Zhi. 1996 Feb;31(2):100-2.
To explore the morphological feature, its pathogenesis and clinical significance of hypoxic-ischemic encephalopathy (HIE) through pathological examinations.
In addition to the routine pathologic examination, the brain tissues, including frontal lobus, temporal lobus, occipital lobus, hippocampus, capsula interna, cerebellum and medullary bulb, were sectioned and examined respectively.
(1) 93.5% of cases had a history of direct or indirect asphyxia. (2) The main pathological alterations were edema, congestion, hyaline thrombosis, haemorrhage, degeneration and necrosis of nerve cells. Softening, calcification, cavity formation and fibrosis were also seen in some cases.
The study suggested that congestion and edema of cerebral tissue were essential changes for the pathogenesis of HIE. Hemorrhage and necrosis were common pathological alterations. Fibrosis and cavitation were changes of convalescence. It is of primary importance to treat asphyxia during perinatal period for the prevention of HIE.
通过病理检查探讨缺氧缺血性脑病（HIE）的形态学特征、发病机制及临床意义。
除常规病理检查外，分别对额叶、颞叶、枕叶、海马、内囊、小脑和延髓等脑组织进行切片检查。
（1）93.5%的病例有直接或间接窒息史。（2）主要病理改变为水肿、充血、透明血栓形成、出血、神经细胞变性和坏死。部分病例还可见软化、钙化、空洞形成和纤维化。
研究表明，脑组织充血和水肿是HIE发病机制的基本改变。出血和坏死是常见的病理改变。纤维化和空洞形成是恢复期的改变。围生期窒息的治疗对预防HIE至关重要。
