Biagioni E, Boldrini A, Bottone U, Pieri R, Cioni G
Stella Maris Scientific Institute, University of Pisa, Calambrone, Italy.
Electroencephalogr Clin Neurophysiol. 1996 Jul;99(1):1-9. doi: 10.1016/0921-884x(96)95649-0.
The prognostic value of abnormal EEG transients was investigated in 362 subjects submitted to EEG recording during the neonatal age and followed-up at least until the 12th month of corrected age. The incidence of negative and positive spikes and sharp waves, of rhythmic sharp theta and delta activities and of alpha discharges were evaluated by means of a quantitative score. These abnormal EEG transients appeared to be generally rare and even absent in a large number of subjects. In infants with normal outcome their incidence tends to increase from low postmenstrual ages towards term period. Full-term newborns with abnormal neurological outcome presented a significantly higher incidence of these transients. Preterm infants with unfavourable evolution showed a higher incidence only when submitted to EEG recording at around term age. However, no difference between subjects with normal and abnormal outcome was detected in preterm infants when evaluated at low postmenstrual ages. The hypothesis that at low postmenstrual ages brain damage might, on the one hand, give rise to abnormal transients and, on the other, alter the "capability' of manifesting them (together with other EEG maturational aspects), might explain these results.
对362名在新生儿期接受脑电图记录并至少随访至矫正年龄12个月的受试者，研究了脑电图异常瞬变的预后价值。通过定量评分评估负性和正性尖波、节律性锐慢波和δ活动以及α波放电的发生率。这些脑电图异常瞬变通常很少见，甚至在大量受试者中不存在。在结局正常的婴儿中，其发生率往往从较低的孕龄期向足月儿期增加。神经学结局异常的足月儿这些瞬变的发生率显著更高。只有在孕龄期左右接受脑电图记录时，预后不良的早产儿这些瞬变的发生率才更高。然而，在低孕龄期评估时，早产儿中结局正常和异常的受试者之间未检测到差异。低孕龄期脑损伤一方面可能导致异常瞬变，另一方面可能改变表现这些瞬变的“能力”（连同脑电图的其他成熟方面），这一假说可能解释了这些结果。
