Abbasi Hamid, Unsworth Charles P
Department of Engineering Science, the University of Auckland, Auckland, New Zealand.
Neural Regen Res. 2020 May;15(5):828-837. doi: 10.4103/1673-5374.268892.
Alongside clinical achievements, experiments conducted on animal models (including primate or non-primate) have been effective in the understanding of various pathophysiological aspects of perinatal hypoxic/ischemic encephalopathy (HIE). Due to the reasonably fair degree of flexibility with experiments, most of the research around HIE in the literature has been largely concerned with the neurodevelopmental outcome or how the frequency and duration of HI seizures could relate to the severity of perinatal brain injury, following HI insult. This survey concentrates on how EEG experimental studies using asphyxiated animal models (in rodents, piglets, sheep and non-human primate monkeys) provide a unique opportunity to examine from the exact time of HI event to help gain insights into HIE where human studies become difficult.
除了临床成果外，在动物模型（包括灵长类或非灵长类）上进行的实验，对于理解围产期缺氧缺血性脑病（HIE）的各种病理生理方面很有成效。由于实验具有相当程度的灵活性，文献中关于HIE的大多数研究主要关注神经发育结局，或者HI发作的频率和持续时间如何与HI损伤后围产期脑损伤的严重程度相关。本综述集中探讨使用窒息动物模型（啮齿动物、仔猪、绵羊和非人类灵长类猴子）进行的脑电图实验研究如何提供一个独特的机会，从HI事件的确切时间开始进行研究，以帮助深入了解人类研究难以开展的HIE。
