Helmus T, Rosenthal L, Bishop C, Roehrs T, Krsevska S, Roth T
Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI 48202, USA.
Electroencephalogr Clin Neurophysiol. 1996 Jul;99(1):10-5. doi: 10.1016/0921-884x(96)95197-8.
Twenty-seven healthy, asymptomatic subjects participated in a study to determine repeated nocturnal sleep latencies as a function of level of daytime sleepiness. Subjects were screened polysomnographically and were determined to be free of any sleep pathology. Nine subjects had a screening multiple sleep latency test (MSLT) of < or = 5 min and 18 had a MSLT of > or = 10 min. Subjects were assigned to 3 groups, sleepy (MSLT < or = 5 min), alert, and alert sleep-deprived groups (MSLT > or = 10 min). Repeated nocturnal latencies to sleep were determined at 2300, 0110, 0310 and 0510 h on 2 nights with at least 5 days between nights. The results showed a main effect of group on the repeated nocturnal sleep latencies. Post-hoc tests demonstrated longer repeated nocturnal latencies among alert subjects compared to the sleepy and alert sleep-deprived subjects. The latter two groups had comparable sleep latencies. A significant main effect of time of night was also shown. The 0510 h latency was significantly shorter than the latencies at 2300 and 0110 h. The 0310 h latency was significantly shorter than the 0110 h latency and comparable to the 2300 and 0510 h latency. Significant correlations were found between daytime MSLT, repeated nocturnal sleep latencies, and nocturnal sleep time. These results show systematic differences in repeated nocturnal sleep latencies among sleep and alert subjects and extend the already described characteristics of these subjects by comparing them to a group of alert sleep-deprived subjects.
27名健康、无症状的受试者参与了一项研究，以确定夜间重复睡眠潜伏期与白天嗜睡程度之间的关系。对受试者进行了多导睡眠图筛查，确定其没有任何睡眠障碍。9名受试者的多次睡眠潜伏期试验（MSLT）结果≤5分钟，18名受试者的MSLT结果≥10分钟。受试者被分为3组，即嗜睡组（MSLT≤5分钟）、警觉组和警觉睡眠剥夺组（MSLT≥10分钟）。在两个晚上的23:00、01:10、03:10和05:10测定夜间重复入睡潜伏期，两晚之间至少间隔5天。结果显示，组间因素对夜间重复睡眠潜伏期有显著影响。事后检验表明，与嗜睡组和警觉睡眠剥夺组相比，警觉组的夜间重复入睡潜伏期更长。后两组的睡眠潜伏期相当。夜间时间因素也有显著的主要影响。05:10的潜伏期明显短于23:00和01:10的潜伏期。03:10的潜伏期明显短于01:10的潜伏期，与23:00和05:10的潜伏期相当。在白天MSLT、夜间重复睡眠潜伏期和夜间睡眠时间之间发现了显著的相关性。这些结果表明，睡眠组和警觉组在夜间重复睡眠潜伏期方面存在系统性差异，并通过将这些受试者与一组警觉睡眠剥夺的受试者进行比较，扩展了已描述的这些受试者的特征。
