Rosenthal L, Bishop C, Helmus T, Krstevska S, Roehrs T, Roth T
Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, Michigan 48202 USA.
Sleep. 1996 May;19(4):290-5. doi: 10.1093/sleep/19.4.290.
Twenty-seven healthy men and women with regular sleep-wake habits (and no habitual napping) participated in a study to determine the relation between auditory awakening thresholds (AAT) and multiple sleep latency test (MSLT) scores. Subjects were free of any sleep complaints and were screened polysomnographically. Nine subjects had a screening MSLT of < or = 5 minutes (sleepy group), and 18 subjects had an MSLT of > or = 10 minutes. Subjects were assigned to three groups: a sleepy group, alert group and an alert sleep-deprived group. Subjects underwent 2 nights of AAT testing with at least 5 days in between each study night. AATs were determined at 0100, 0300, 0500 and 0730 hours. There were a total of 209 available AAT determinations, with a comparable number of trials across the groups. Because 68% of AAT determinations were done out of stage 2 non-rapid eye movement (NREM) sleep, the thrust of the analysis was based on the results of this stage of sleep. The AATs were averaged across the two experimental nights. Trials 1 and 2 (first half of the night) and 3 and 4 (second half of the night) were averaged for each subject. There was no main effect of group on AATs. However, there was a significant main effect of time and a significant group by time interaction. The former indicated an overall decline in AATs across the night. More importantly, the three groups had comparable AAT levels during the first half of the night:. Sleepy and alert-deprived subjects, however, failed to show a decline in AATs, whereas the alert group showed a significant decline in the second half of the night. This differential rate of decline in AATs is suggested to be related to the differences in sleep homeostasis among alert and sleepy individuals.
27名有规律睡眠-觉醒习惯（且无习惯性午睡）的健康男性和女性参与了一项研究，以确定听觉觉醒阈值（AAT）与多次睡眠潜伏期试验（MSLT）得分之间的关系。受试者无任何睡眠问题，并接受了多导睡眠图筛查。9名受试者的筛查MSLT结果为≤5分钟（嗜睡组），18名受试者的MSLT结果为≥10分钟。受试者被分为三组：嗜睡组、清醒组和清醒睡眠剥夺组。受试者进行了两晚的AAT测试，每个研究夜晚之间至少间隔5天。在凌晨1点、3点、5点和7点30分测定AAT。共有209次可用的AAT测定，各小组的试验次数相当。由于68%的AAT测定是在非快速眼动睡眠（NREM）的第2阶段进行的，因此分析的重点基于该睡眠阶段的结果。将两个实验夜晚的AAT进行平均。对每个受试者的第1次和第2次试验（前半夜）以及第3次和第4次试验（后半夜）进行平均。组对AAT没有主要影响。然而，时间有显著的主要影响，且组与时间存在显著的交互作用。前者表明AAT在整个夜间总体下降。更重要的是，三组在前半夜的AAT水平相当。然而，嗜睡组和清醒睡眠剥夺组的受试者在AAT上没有下降，而清醒组在后半夜AAT显著下降。AAT下降的这种差异速率被认为与清醒和嗜睡个体之间睡眠稳态的差异有关。
