黄斑色素光密度的性别差异：与血浆类胡萝卜素浓度及饮食模式的关系。

Sex differences in macular pigment optical density: relation to plasma carotenoid concentrations and dietary patterns.

作者信息

Hammond B R, Curran-Celentano J, Judd S, Fuld K, Krinsky N I, Wooten B R, Snodderly D M

机构信息

Schepens Eye Research Institute, Boston, MA 02114, USA.

出版信息

Vision Res. 1996 Jul;36(13):2001-12. doi: 10.1016/0042-6989(95)00290-1.

DOI:10.1016/0042-6989(95)00290-1

PMID:8759440

Abstract

Sex differences in macular pigment (MP) optical density (measured psychophysically) were examined. Concentrations of lutein and zeaxanthin (L and Z) (non-separated) and beta-carotene (BC) in the blood were determined using reverse phase high-performance liquid chromatography. Dietary intake of L and Z, BC, fat, and iron were estimated by questionnaire. Males had 38% higher MP density than females (P < 0.001) despite similar plasma carotenoid concentrations and similar dietary intake (except for fat). Dietary intake of carotenoids, fat and iron, as well as plasma concentrations of L and Z were positively related to MP density in males. Conversely, only plasma L and Z was related to MP density for females, and dietary fat was negatively related to MP density. Sex differences in protection of the retina by MP and in the relationship between the retina, blood and diet could be a factor in the incidence of retinal diseases, especially age-related macular degeneration.

摘要

研究了黄斑色素（MP）光学密度（通过心理物理学测量）的性别差异。使用反相高效液相色谱法测定血液中叶黄素和玉米黄质（L和Z）（未分离）以及β-胡萝卜素（BC）的浓度。通过问卷调查估算L和Z、BC、脂肪和铁的膳食摄入量。尽管血浆类胡萝卜素浓度和膳食摄入量相似（脂肪除外），但男性的MP密度比女性高38%（P < 0.001）。男性的类胡萝卜素、脂肪和铁的膳食摄入量以及血浆L和Z浓度与MP密度呈正相关。相反，对于女性而言，只有血浆L和Z与MP密度相关，而膳食脂肪与MP密度呈负相关。MP对视网膜的保护作用以及视网膜、血液和饮食之间关系的性别差异可能是视网膜疾病发病率的一个因素，尤其是年龄相关性黄斑变性。