Saraux A, Allain J, Guedes C, Baron D, Youinou P, Le Goff P
Unit of Rheumatology, Brest University Medical School Hospital, France.
Br J Rheumatol. 1996 Aug;35(8):752-4. doi: 10.1093/rheumatology/35.8.752.
The aim of this study was to evaluate the prevalence of Raynaud's phenomenon in patients with rheumatoid arthritis (RA), and to relate this symptom to clinical, radiological and serological characteristics of the patients. All relevant information was retrospectively obtained from the standardized clinical records of 322 RA in-patients first admitted to the Rheumatology Unit of Brest University Medical School. Raynaud's phenomenon was found in 54 (17.2%) of 322 RA patients. There was no significant correlation between demographic, clinical or radiological characteristics. However, the subgroup of RA patients with Raynaud's phenomenon had a slightly higher prevalence of vasculitis than the subgroup without Raynaud's phenomenon. CRP level and C4 level were found to be lower in the former than in the latter group, whereas ESR and various serological findings (rheumatoid factor, antinuclear antibodies) were comparable in the two groups. We conclude that the prevalence of Raynaud's phenomenon is high in French RA in-patients, and that some clinical and biological abnormalities (vasculitis, low CRP level and low C4 level) suggest an association between Raynaud's phenomenon and vasculitis in a few cases, whereas this association might be fortuitous in the remainder.
本研究的目的是评估类风湿关节炎（RA）患者中雷诺现象的患病率，并将该症状与患者的临床、放射学和血清学特征相关联。所有相关信息均从布雷斯特大学医学院风湿病科首次收治的322例RA住院患者的标准化临床记录中回顾性获取。322例RA患者中有54例（17.2%）出现雷诺现象。人口统计学、临床或放射学特征之间无显著相关性。然而，有雷诺现象的RA患者亚组中血管炎的患病率略高于无雷诺现象的亚组。发现前一组的CRP水平和C4水平低于后一组，而两组的ESR和各种血清学检查结果（类风湿因子、抗核抗体）相当。我们得出结论，法国RA住院患者中雷诺现象的患病率较高，并且一些临床和生物学异常（血管炎、低CRP水平和低C4水平）表明在少数情况下雷诺现象与血管炎之间存在关联，而在其余情况下这种关联可能是偶然的。
