Ladeb S, Durand-Gasselin B, Leclercq R, Astier A, Cordonnier C
Service d'Hématologie Clinique, Hôpital Henri-Mondor, Créteil, France.
Pathol Biol (Paris). 1996 Feb;44(2):107-12.
Because they receive many infected patients with various degrees of immunosuppression, the haematology departments have a high consumption of antibiotics. The possible relationship between antibiotic consumption and bacterial resistance is discussed in many specialities, especially for some classes like quinolones. This possible relationship has to be evocated in haematology where patients are at high risk of severe sepsis because of neutropenia. In Henri Mondor hospital, we studied the evolution of bacterial susceptibility and of antibiotic consumption in the haematology unit on a 6 year period. We found that this susceptibility was finally stable over time. The main factors which may influence the evolution of the bacterial susceptibility in our study, and in the literature are discussed.
由于血液科接收许多患有不同程度免疫抑制的感染患者，所以抗生素消耗量很大。许多专业领域都在探讨抗生素消耗与细菌耐药性之间的可能关系，尤其是对于喹诺酮类等某些类别。在血液科必须提及这种可能的关系，因为由于中性粒细胞减少，患者有发生严重脓毒症的高风险。在亨利·蒙多医院，我们研究了血液科6年间细菌敏感性和抗生素消耗的变化情况。我们发现这种敏感性最终随时间保持稳定。本文讨论了在我们的研究以及文献中可能影响细菌敏感性变化的主要因素。
