Paty E, Paupe J, de Blic J, Scheinmann P
Service de pneumologie et d'allergologie pédiatriques, Hôpital Necker-Enfants Malades, Paris.
Rev Prat. 1996 Apr 15;46(8):975-9.
Epidemiologic data have shown an increased prevalence (and severity) of atopy related diseases (asthma, eczema and allergic rhinitis) during the post 15-20 years. Atopic respiratory diseases such as allergic rhinitis and asthma represent the effects of an immunological response to allergens, mediated through immunoglobulins E. Development of a clinically significant atopic reaction depends on environmental exposure. The majority of allergic children display positive skin tests to house dust mites, animal danders or pollens. Immediate hypersensitivity to food allergens starts early in life and is most often associated with atopic dermatitis. Allergic reactions to peanuts are generally acute and severe, with an increasing frequency. Parents must be aware of their child's problem and preventive measures must be undertaken very early in life, first at home and later also at school. Family history remains the best predictor of atopy in newborn babies.
流行病学数据显示,在过去15至20年中,特应性相关疾病(哮喘、湿疹和过敏性鼻炎)的患病率(以及严重程度)有所上升。过敏性鼻炎和哮喘等特应性呼吸道疾病代表了通过免疫球蛋白E介导的对过敏原的免疫反应的影响。临床上显著的特应性反应的发生取决于环境暴露。大多数过敏儿童对屋尘螨、动物皮屑或花粉的皮肤试验呈阳性。对食物过敏原的速发型超敏反应在生命早期就开始出现,并且最常与特应性皮炎相关。对花生的过敏反应通常是急性且严重的,且频率不断增加。家长必须了解孩子的问题,并且必须在生命早期就采取预防措施,首先是在家中,随后在学校也应如此。家族病史仍然是新生儿特应性的最佳预测指标。