Wen S W, Simunovic M, Williams J I, Johnston K W, Naylor C D
Institute for Clinical Evaluative Sciences in Ontario, North York.
J Epidemiol Community Health. 1996 Apr;50(2):207-13. doi: 10.1136/jech.50.2.207.
To determine, for abdominal aortic aneurysm surgery, whether a previously reported relationship between hospital case volume and mortality rate was observed in Ontario hospitals and to assess the potential impact of age on the mortality rate for elective surgery.
Population based observational study using administrative data.
All Ontario hospitals where repair of abdominal aortic aneurysm as a primary procedure was performed during 1988-92.
These comprised 5492 patients with unruptured abdominal aortic aneurysms and 1203 patients with ruptured abdominal aortic aneurysms admitted to hospital between 1988-92 for repair of abdominal aortic aneurysm as a primary procedure.
In-hospital death and length of in-hospital stay.
The case fatality rate was 3.8% for unruptured abdominal aortic aneurysms and 40.0% for ruptured abdominal aortic aneurysms. For unruptured cases, after adjustment for patient and hospital covariates, each 10 case per year increase in hospital volume was related to a 6% reduction in relative odds of death (odds ratio (OR) 0.94, 95% confidence intervals 0.88, 0.99) and 0.29 days reduction (95% CI -0.22, -0.35) in postoperative in-hospital stay. Female sex (OR 1.53, 95% CI 1.08, 2.18) and transfer from another acute care hospital (OR 4.37, 95% CI 2.62, 7.29) were associated with increased case fatality rates among patients in the unruptured category. For ruptured cases, neither the case fatality rate nor postoperative in-hospital stay were significantly related to hospital volume. The case fatality rates increased linearly and substantially with advancing age both for unruptured and ruptured aneurysms, and the excess risk of postoperative death in ruptured as compared to unruptured aneurysms was substantially higher in older patients.
The relationship between hospital volume and mortality or morbidity was very modest and observed only for elective surgery. Case fatality rates in patients with ruptured abdominal aortic aneurysms remained 10 times higher than for patients with unruptured abdominal aortic aneurysms, despite improvements in overall mortality in comparison to previously published data. More effective detection of aneurysms, including elective repair for those once considered "high risk" older patients, might further reduce the toll from ruptured aortic aneurysms.
确定在安大略省的医院中,腹主动脉瘤手术是否存在先前报道的医院病例数量与死亡率之间的关系,并评估年龄对择期手术死亡率的潜在影响。
基于人群的观察性研究,使用行政数据。
1988 - 1992年期间,安大略省所有将腹主动脉瘤修复作为主要手术的医院。
这些患者包括1988 - 1992年间因腹主动脉瘤修复作为主要手术而入院的5492例未破裂腹主动脉瘤患者和1203例破裂腹主动脉瘤患者。
住院死亡和住院时间。
未破裂腹主动脉瘤的病死率为3.8%,破裂腹主动脉瘤的病死率为40.0%。对于未破裂病例,在对患者和医院协变量进行调整后,医院病例数量每增加10例/年,死亡相对比值降低6%(比值比(OR)0.94,95%置信区间0.88,0.99),术后住院时间缩短0.29天(95% CI -0.22,-0.35)。女性(OR 1.53,95% CI 1.08,2.18)和从另一家急性护理医院转来(OR 4.37,95% CI 2.62,7.29)与未破裂类患者的病死率增加相关。对于破裂病例,病死率和术后住院时间均与医院病例数量无显著关系。未破裂和破裂动脉瘤的病死率均随年龄增长呈线性且大幅增加,与未破裂动脉瘤相比,破裂动脉瘤术后死亡的额外风险在老年患者中更高。
医院病例数量与死亡率或发病率之间的关系非常微弱,且仅在择期手术中观察到。尽管与先前公布的数据相比总体死亡率有所改善,但破裂腹主动脉瘤患者的病死率仍比未破裂腹主动脉瘤患者高10倍。更有效地检测动脉瘤,包括对那些曾被视为“高危”的老年患者进行择期修复,可能会进一步降低主动脉瘤破裂造成的损失。