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腹主动脉瘤破裂:早期并发症和死亡的预测因素

Ruptured abdominal aortic aneurysms: predictors for early complications and death.

作者信息

Bauer E P, Redaelli C, von Segesser L K, Turina M I

机构信息

Heartcenter Bodensee, Kreuzlingen, Switzerland.

出版信息

Surgery. 1993 Jul;114(1):31-5.

PMID:8356523
Abstract

BACKGROUND

Urgent operation for ruptured aneurysm is still associated with a high operative mortality rate. The purpose of the study was to determine the risk factors that truly influence early complications and death.

METHODS

Between 1979 and 1991, 314 consecutive patients with a mean age of 69 years were treated surgically for a ruptured infrarenal abdominal aortic aneurysm. Twenty-two preoperative, perioperative, and intraoperative variables were subjected to a multivariate analysis to identify the independent predictors.

RESULTS

Early death occurred in 92 (29%) of 340 patients. Significant primary predictors for early death were duration of cross-clamp (p < 0.0001), preoperative shock (p = 0.0005), suprarenal cross clamp (p = 0.002), and a history of coronary artery disease (CAD) (p = 0.004). The following postoperative complications were risk factors for death: myocardial failure (p < 0.0001), renal failure (p < 0.0001), sepsis (p = 0.01), and colon ischemia (p = 0.03). Predictors for postoperative myocardial insufficiency were a history of CAD (p < 0.0001), amount of intraoperative volume substitution (p < 0.0001), suprarenal cross clamp (p = 0.0007), and preoperative shock (p = 0.05).

CONCLUSIONS

Preoperative and perioperative risk factors that result in fatal postoperative complications can be partially influenced by the surgeon. Short clamping time and infrarenal position of aortic clamp may lower overall early mortality rates. A history of CAD is a highly significant predictor for postoperative complications and early death.

摘要

背景

破裂性动脉瘤的急诊手术死亡率仍然很高。本研究的目的是确定真正影响早期并发症和死亡的危险因素。

方法

1979年至1991年间,314例平均年龄69岁的连续性患者接受了手术治疗,以处理肾下腹主动脉瘤破裂。对22个术前、围手术期和术中变量进行多变量分析,以确定独立预测因素。

结果

340例患者中有92例(29%)早期死亡。早期死亡的重要主要预测因素是阻断时间(p < 0.0001)、术前休克(p = 0.0005)、肾动脉以上阻断(p = 0.002)和冠状动脉疾病(CAD)史(p = 0.004)。以下术后并发症是死亡的危险因素:心肌衰竭(p < 0.0001)、肾衰竭(p < 0.0001)、败血症(p = 0.01)和结肠缺血(p = 0.03)。术后心肌功能不全的预测因素是CAD史(p < 0.0001)、术中补液量(p < 0.0001)、肾动脉以上阻断(p = 0.0007)和术前休克(p = 0.05)。

结论

导致致命术后并发症的术前和围手术期危险因素可部分受外科医生影响。缩短阻断时间和主动脉夹的肾下位置可能会降低总体早期死亡率。CAD史是术后并发症和早期死亡的高度显著预测因素。

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