Fan Q, Allen P W
Department of Pathology, First Affilated Hospital of Nanjing Medical University.
Zhonghua Bing Li Xue Za Zhi. 1996 Feb;25(1):30-2.
By clinical, pathologic and immunohistochemical study on aniomatoid malignant fibrous histiocytoma, which is a relatively uncommon soft tissue tumor described by Enzinger in 1979, and often misdiagnosed, we are reporting 32 cases of this lesion. The distinctive histopathology were: (1) Cystic change filled with hemorrhagic fluid or blood, (2) surrounded by nests of fibroblastlike and histocyte-like cells and (3) intermingled with chronic inflammatory cells, (4) often surrounded by a fibrous pseudocapsule. Immunohistochemical staining done in 4 cases showed all to be positive in lysozyme, three positive in Mac 387 and CD 68. These results support their histiocytic origin. Follow-up information was available in 25 of 32 cases. All the 25 patients were alive, 4 with recurrence (16%), 1 with metastasis (4%). These results concur with the opinion that intrinsically, this is a low grade tumor.
通过对1979年由恩津格描述的相对罕见的软组织肿瘤——非典型性恶性纤维组织细胞瘤进行临床、病理及免疫组织化学研究，该肿瘤常被误诊，我们报告了32例此病变。其独特的组织病理学表现为：（1）充满血性液体或血液的囊性改变；（2）被成纤维细胞样和组织细胞样细胞巢所围绕；（3）与慢性炎症细胞混合；（4）常被纤维性假包膜所包绕。对4例进行的免疫组织化学染色显示，所有病例溶菌酶均呈阳性，3例Mac 387和CD 68呈阳性。这些结果支持它们的组织细胞起源。32例中有25例可获得随访信息。所有25例患者均存活，4例复发（16%），1例转移（4%）。这些结果与该肿瘤本质上是低度恶性肿瘤的观点一致。
