Guan M Z, Wang N G
Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing.
Yao Xue Xue Bao. 1996;31(1):10-2.
Treatment of rats with (+/-) gossypol 80 mg.kg-1 or (-) gossypol 40 mg.kg-1 on day 6-9 of gestation terminated early pregnancy. However, (+) gossypol at the dosage of 40 mg.kg-1 was found to have no effect on gestation. (-) Gossypol at a concentration of 30 micrograms.ml-1 showed an inhibitory effect on progesterone production and (+) gossypol at 10 micrograms.ml-1 caused an increase of progesterone secretion by luteal cells in vitro. A marked increase of progesterone level in granulosa cells was elicited by hCG. The steroidogenic response of granulosa cells to hCG was inhibited by (+/-) gossypol at 10 and 30 micrograms.ml-1.
在妊娠第6至9天，用80毫克/千克体重的（±）棉酚或40毫克/千克体重的（-）棉酚处理大鼠可终止早期妊娠。然而，发现40毫克/千克体重剂量的（+）棉酚对妊娠没有影响。浓度为30微克/毫升的（-）棉酚对孕酮生成有抑制作用，而浓度为10微克/毫升的（+）棉酚在体外可使黄体细胞的孕酮分泌增加。人绒毛膜促性腺激素（hCG）可引起颗粒细胞中孕酮水平显著升高。浓度为10和30微克/毫升的（±）棉酚可抑制颗粒细胞对hCG的类固醇生成反应。
