Tang B, Cheng Z, Huang Y
Department of Cardiology, First Affiliated Hospital, Xinjiang Medical College.
Zhonghua Jie He He Hu Xi Za Zhi. 1995 Oct;18(5):303-5, 319.
In 20 patients of cor pulmonale with heart failure and respiratory failure and in 11 healthy men, after intravenous captopril injection, acute hemodynamic and hormonal change were observed. The results indicated that intravenous captopril injection rapidly reduced cardiac preload and afterload, reduced pulmonary arterial pressure, increased cardiac output, inhibited renin system activity, decreased plasma level of thyroxin and atrial natriuretic peptide. A rapid symptomatic improvement in patients with acute or severe cor pulmonale was shown and there was no significant effect on blood gas immediately.
在20例患有心力衰竭和呼吸衰竭的肺心病患者以及11名健康男性中，静脉注射卡托普利后，观察到急性血流动力学和激素变化。结果表明，静脉注射卡托普利可迅速降低心脏前负荷和后负荷，降低肺动脉压，增加心输出量，抑制肾素系统活性，降低血浆甲状腺素和心房利钠肽水平。急性或重度肺心病患者症状迅速改善，且对血气立即无显著影响。
