Weng N, Hu W, Sun X, Li L, Fu S
Department of Ophthalmology, Beijing Tong Ren Hospital.
Zhonghua Yan Ke Za Zhi. 1995 Nov;31(6):403-11.
In order to investigate the clinical features, pathology and treatment of idiopathic uveal effusion syndrome, ten eyes of seven patients with the syndrome had been studied. In addition to general clinical examinations, indirect opthalmoscopy, fundus fluorescein angiography and (FFA) ultrasonography were used to make definite diagnoses. The findings of these examinations indicate four key features of the idiopathic uveal effusion syndrome. They are: annular cilio-choroidal detachment, shifting non-rhegmatogenous retinal detachment, unremarkable inflammation in the anterior segment, and normal intraocular pressure. The fundus change is characterized by the "leopard-spot". All patients were treated by sclerectomy and sclerotomy, ciliochoroidal detachments disappeared soon after surgery, and retinal detachments resolved later on. Patients' visual acuity recovered well. The histochemical and electron microscopic examinations of excised tissues from five eyes showed thickened sclera, a general increase of the scleral fibril width compared to normal scleral, the disruption of normal lamellar arrangement of the scleral fibers and the deposition of glycosaminoglycans in the interfibrillar spaces. All these indicate that a congenital scleral abnormality seems to be the basic pathophysiology of the idiopathic uveal effusion syndrome.
为了研究特发性葡萄膜渗漏综合征的临床特征、病理及治疗方法，对7例该综合征患者的10只眼进行了研究。除常规临床检查外，还采用间接检眼镜、眼底荧光血管造影（FFA）及超声检查以明确诊断。这些检查结果显示了特发性葡萄膜渗漏综合征的四个关键特征。它们是：环形睫状体脉络膜脱离、可移动的非孔源性视网膜脱离、前段炎症不明显以及眼压正常。眼底改变以“豹斑”为特征。所有患者均接受了巩膜切除术和巩膜切开术治疗，术后睫状体脉络膜脱离很快消失，视网膜脱离随后得到缓解。患者视力恢复良好。对5只眼切除组织的组织化学和电子显微镜检查显示，巩膜增厚，与正常巩膜相比巩膜纤维宽度普遍增加，巩膜纤维正常板层排列破坏，糖胺聚糖沉积于纤维间隙。所有这些表明先天性巩膜异常似乎是特发性葡萄膜渗漏综合征的基本病理生理学改变。
