Morens D M, Zweighaft R M, Vernon T M, Gary G W, Eslien J J, Wood B T, Holman R C, Dolin R
Lancet. 1979 May 5;1(8123):964-6. doi: 10.1016/s0140-6736(79)91734-3.
In December, 1976, an outbreak of gastroenteritis occurred at a resort camp in Colorado. Data obtained by questionnaire from 760 persons indicated that 418 (55%) had had gastroenteritis at the camp or within a week of leaving it, with peak onset within a two-day period. Symptoms included vomiting (81%), diarrhoea (65%), and fever (49%); median duration of illness was twenty-four hours. The attack-rate increased with consumption of water or ice-containing beverages. The camp water supply was found to be inadequately chlorinated and contaminated by a leaking septic tank. Although routine laboratory tests did not reveal bacterial, viral, or parasitic pathogens, immune electron microscopy detected virus-like particles in two of five diarrhoeal stool filtrates. Oral administration of one of these bacteria-free filtrates to two volunteers induced a gastrointestinal illness similar to that observed in the camp visitors.
1976年12月，科罗拉多州的一个度假营地爆发了肠胃炎。通过问卷调查从760人那里获得的数据表明，418人（55%）在营地或离开营地一周内患了肠胃炎，发病高峰在两天内。症状包括呕吐（81%）、腹泻（65%）和发烧（49%）；疾病的中位持续时间为24小时。发病率随着饮用含冰饮料而增加。发现营地的供水氯化不足且被一个泄漏的化粪池污染。虽然常规实验室检测未发现细菌、病毒或寄生虫病原体，但免疫电子显微镜在五份腹泻粪便滤液中的两份中检测到了病毒样颗粒。给两名志愿者口服其中一份无菌滤液后引发了与营地游客中观察到的类似的胃肠道疾病。
