Dolin R, Reichman R C, Roessner K D, Tralka T S, Schooley R T, Gary W, Morens D
J Infect Dis. 1982 Aug;146(2):184-9. doi: 10.1093/infdis/146.2.184.
An extensive outbreak of acute gastroenteritis of unknown etiology occurred at Snow Mountain, Colorado, in December 1976. Virus-like particles, 27 nm in diameter, were observed by electron microscopy in two of five stool specimens from individuals in the outbreak. Oral administration of a filtrate from one of the specimens induced disease in nine of 12 normal volunteers. Experimentally induced illness was similar to that observed during the outbreak. Stool specimens examined by immune electron microscopy revealed 27-nm virus-like particles in three of nine ill volunteers at the onset of illness. When the particles were used as a source of antigen, increases in levels of serum antibody were demonstrated in persons with either experimentally induced or naturally occurring illness. Therefore, it is likely that this virus-like particle is the etiologic agent of the Snow Mountain outbreak. The Snow Mountain agent appears to be morphologically similar to, but antigenically distinct from, the Norwalk and Hawaii agents by immune electron microscopy and may represent an additional antigenic type among the agents that resemble the Norwalk particle.
1976年12月，科罗拉多州雪山地区发生了一起病因不明的急性肠胃炎大规模爆发事件。通过电子显微镜观察，在此次疫情中5名患者的粪便样本里，有2份检测到了直径为27纳米的病毒样颗粒。对其中一份样本的滤液进行口服后，12名正常志愿者中有9人发病。实验诱发的疾病与疫情期间观察到的症状相似。通过免疫电子显微镜检查粪便样本发现，9名患病志愿者中有3人在发病初期出现了27纳米的病毒样颗粒。当将这些颗粒用作抗原来源时，无论是实验诱发疾病还是自然发病的人，其血清抗体水平都有所升高。因此，这种病毒样颗粒很可能是雪山地区疫情的病原体。通过免疫电子显微镜观察，雪山病原体在形态上似乎与诺沃克和夏威夷病原体相似，但在抗原性上有所不同，它可能代表了类似诺沃克颗粒的病原体中的另一种抗原类型。
