Tan G H, Carney J A, Grant C S, Young W F
Division of Endocrinology Metabolism and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
Clin Endocrinol (Oxf). 1996 May;44(5):603-9. doi: 10.1046/j.1365-2265.1996.709530.x.
The coexistence of phaeochromocytoma and primary aldosteronism is rare. In the four cases reported in the English literature, adrenal gland involvement was unilateral. The case we report is unusual in that both adrenal glands were affected. Our patient was a 63-year-old man who presented with long-standing hypertension and hypokalaemia. Evaluation for secondary hypertension showed biochemical evidence of both phaeochromocytoma and primary aldosteronism. Bilateral adrenal masses were found on imaging studies. Right total and left partial adrenalectomy were performed. Pathological examination revealed bilateral phaeochromocytomas, with cortical findings consistent with mild cortical hyperplasia. Annual biochemical evaluation over a 2-year period has shown no evidence of recurrent disease. To our knowledge, this is the first reported case in the English-language literature of phaeochromocytomas involving both adrenal glands coexisting with hyperaldosteronism.
嗜铬细胞瘤与原发性醛固酮增多症并存的情况较为罕见。英文文献报道的4例中，肾上腺受累均为单侧。我们报告的该病例不同寻常之处在于双侧肾上腺均受到影响。我们的患者是一名63岁男性，有长期高血压和低钾血症病史。继发性高血压评估显示有嗜铬细胞瘤和原发性醛固酮增多症的生化证据。影像学检查发现双侧肾上腺肿块。行右侧肾上腺全切和左侧肾上腺部分切除术。病理检查显示双侧嗜铬细胞瘤，皮质表现符合轻度皮质增生。在2年期间的年度生化评估未发现复发疾病的证据。据我们所知，这是英文文献中首次报道的双侧肾上腺嗜铬细胞瘤与醛固酮增多症并存的病例。
