Verdonck P, Segers P, Missault L, Verhoeven R
Hydraulics Laboratory, University of Gent, Belgium.
Med Biol Eng Comput. 1996 May;34(3):192-8. doi: 10.1007/BF02520073.
A fluid dynamics model of mitral valve motion during diastolic filling of the left heart is described. Given a pulsed Doppler velocity pattern in the mitral annulus, the radius of circular mitral orifice, the length of leaflets and the end-systolic left ventricular volume, the numerical model predicts the time course of the mitral leaflets during diastole: the mitral valve M-mode echocardiogram. Results obtained by computer simulation have been validated with in vivo data. It is shown that mitral valve flow is essentially a fluid dynamics process of floating mitral valve leaflets with blood flow due to the atrioventricular pressure gradient. In addition, a partial opening of the mitral valve as the initial boundary condition is required to simulate the overshooting of the leaflets during early peak filling. Some back flow is a condition for perfect closing of the native mitral valve. The higher the unsteady character of mitral flow, the less efficient is the opening and closing processes of the mitral valve.
本文描述了左心舒张期充盈时二尖瓣运动的流体动力学模型。给定二尖瓣环处的脉冲多普勒速度模式、二尖瓣圆形孔口半径、瓣叶长度和收缩末期左心室容积，该数值模型可预测舒张期二尖瓣瓣叶的时间进程，即二尖瓣M型超声心动图。通过计算机模拟获得的结果已用体内数据进行了验证。结果表明，二尖瓣血流本质上是一个由于房室压力梯度导致二尖瓣瓣叶随血流漂浮的流体动力学过程。此外，需要将二尖瓣的部分开放作为初始边界条件，以模拟早期充盈峰值时瓣叶的过冲现象。一些反流是天然二尖瓣完美关闭的条件。二尖瓣血流的非定常特性越高，二尖瓣的开放和关闭过程效率越低。
