Uesugi Y, Aiba S, Usuba M, Tagami H
Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan.
Br J Dermatol. 1996 Jun;134(6):1098-100.
Acne agminata (lupus miliaris disseminatus faciei), once regarded as a tuberculide, is a facial granulomatous disease still seen in young adults in Japan, despite a decrease in the incidence of tuberculosis. Although most lesions regress within a few years, even without treatment, disfiguring scars remain on the face. We have evaluated the efficacy of low dose oral prednisone therapy because, in the past, there has been no satisfactory therapy for this condition. We have treated four patients with acne agminata with prednisone, at first 10 mg daily for 2 weeks, decreasing to 5 mg daily for 3 months. This modest dosage was found to give an excellent result in three patients and a poor result in one whose treatment was started at a much later stage of the disease than in the others. Acne agminata can be cured without scar formation when oral steroids are started in an early phase of the disease.
聚集性痤疮（面部播散性粟粒狼疮）曾被视为一种结核疹，尽管结核病发病率有所下降，但在日本的年轻人中仍可见到这种面部肉芽肿性疾病。尽管大多数皮损即使未经治疗也会在几年内消退，但面部仍会留下毁容性疤痕。我们评估了小剂量口服泼尼松治疗的疗效，因为过去针对这种情况没有令人满意的治疗方法。我们用泼尼松治疗了4例聚集性痤疮患者，开始时每日10毫克，持续2周，然后减至每日5毫克，持续3个月。发现这种适度剂量对3例患者效果极佳，对1例患者效果不佳，该患者在疾病后期才开始治疗，比其他患者晚得多。在疾病早期开始口服类固醇时，聚集性痤疮可以治愈且不会形成疤痕。
