Gabastou J M, Nugon-Baudon L, Robert Y, Manuel C, Vaissade P, Bourgeon E, Sibeud M, Szylit O, Bourlioux P
Centre Hospitalier Perray-Vaucluse, EPINAY SUR ORGE, France.
Pathol Biol (Paris). 1996 Apr;44(4):275-81.
Implication of amines in central nervous system diseases such as migraine, Parkinson disease, epilepsy and depressive illness, is well established. On an other hand, intestinal flora is responsible for the production of specific metabolites such as amines, particularly histamine, tyramine, putrescine and cadaverine. These amines can be absorbed in situ and, through unknown mechanisms, may affect the host's behavior. Most of the data about the pathological activities of bacterial amines concern animals. The concentrations of histamine, tyramine, putrescine and cadaverine in the feces of the studied "controls" appeared steady over time. For the patient presenting clastic crisis without any starting factor, variations appear to overcome the "controls" values, with a great variability. At least tyramine, putrescine and cadaverine concentrations variations are striking by superposed and seem associated to the arising hyper agressivity crisis.
胺类物质在偏头痛、帕金森病、癫痫和抑郁症等中枢神经系统疾病中的作用已得到充分证实。另一方面，肠道菌群负责产生特定的代谢产物，如胺类，特别是组胺、酪胺、腐胺和尸胺。这些胺类可以在原位被吸收，并通过未知机制影响宿主行为。关于细菌胺类病理活性的大多数数据都来自动物研究。研究中“对照组”粪便中组胺、酪胺、腐胺和尸胺的浓度随时间保持稳定。对于没有任何诱发因素而出现爆发性危机的患者，其胺类浓度变化似乎超过了“对照组”的值，且变化很大。至少酪胺、腐胺和尸胺浓度的变化叠加明显，似乎与出现的过度攻击性危机有关。
