多瘤病毒小T抗原增强病毒基因组在3T6小鼠成纤维细胞中的复制。
Polyomavirus small T antigen enhances replication of viral genomes in 3T6 mouse fibroblasts.
作者信息
Berger H, Wintersberger E
出版信息
J Virol. 1986 Nov;60(2):768-70. doi: 10.1128/JVI.60.2.768-770.1986.
Abstract
Transfection of 3T6 cells with a cloned polyomavirus genome encoding only large T antigen resulted in DNA replication with only about 1/10 the efficiency of wild-type viral DNA coding for all three T antigens. This replication defect was at least in part overcome by the simultaneous transfections of polyomavirus genomes which allowed the expression of small T antigen. We conclude that polyomavirus small T antigen has a (probably indirect) role in replication.
摘要
用仅编码大T抗原的克隆多瘤病毒基因组转染3T6细胞，导致DNA复制，其效率仅为编码所有三种T抗原的野生型病毒DNA的约1/10。同时转染允许小T抗原表达的多瘤病毒基因组至少部分克服了这种复制缺陷。我们得出结论，多瘤病毒小T抗原在复制中具有（可能是间接的）作用。
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