• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Protection against myxomatosis and rabbit viral hemorrhagic disease with recombinant myxoma viruses expressing rabbit hemorrhagic disease virus capsid protein.用表达兔出血性疾病病毒衣壳蛋白的重组黏液瘤病毒预防黏液瘤病和兔病毒性出血病
J Virol. 1996 Aug;70(8):5061-6. doi: 10.1128/JVI.70.8.5061-5066.1996.
2
Horizontal transmissible protection against myxomatosis and rabbit hemorrhagic disease by using a recombinant myxoma virus.利用重组黏液瘤病毒对黏液瘤病和兔出血性疾病进行水平传播性保护。
J Virol. 2000 Feb;74(3):1114-23. doi: 10.1128/jvi.74.3.1114-1123.2000.
3
Protection of rabbits against rabbit viral haemorrhagic disease with a vaccinia-RHDV recombinant virus.用痘苗-RHDV重组病毒保护兔子免受兔病毒性出血病侵害。
Vaccine. 1996 Apr;14(6):506-10. doi: 10.1016/0264-410x(95)00232-p.
4
First field trial of a transmissible recombinant vaccine against myxomatosis and rabbit hemorrhagic disease.针对兔黏液瘤病和兔出血性疾病的可传播重组疫苗的首次田间试验。
Vaccine. 2001 Aug 14;19(31):4536-43. doi: 10.1016/s0264-410x(01)00184-0.
5
Safety evaluation of a recombinant myxoma-RHDV virus inducing horizontal transmissible protection against myxomatosis and rabbit haemorrhagic disease.一种诱导对黏液瘤病和兔出血性疾病产生水平传播性保护作用的重组黏液瘤-兔出血症病毒的安全性评估。
Vaccine. 2000 Sep 15;19(2-3):174-82. doi: 10.1016/s0264-410x(00)00183-3.
6
Novel bivalent vectored vaccine for control of myxomatosis and rabbit haemorrhagic disease.用于控制黏液瘤病和兔出血症的新型双价载体疫苗。
Vet Rec. 2012 Mar 24;170(12):309. doi: 10.1136/vr.100366. Epub 2012 Jan 21.
7
Recombinant canine adenovirus type 2 expressing rabbit hemorrhagic disease virus VP60 protein provided protection against RHD in rabbits.表达兔出血症病毒 VP60 蛋白的重组犬 2 型腺病毒可对兔提供针对 RHD 的保护。
Vet Microbiol. 2018 Jan;213:15-20. doi: 10.1016/j.vetmic.2017.11.007. Epub 2017 Nov 6.
8
Single dose adenovirus vectored vaccine induces a potent and long-lasting immune response against rabbit hemorrhagic disease virus after parenteral or mucosal administration.单剂量腺病毒载体疫苗经肠胃外或粘膜给药后，可诱导针对兔出血症病毒的强效持久免疫反应。
Vet Immunol Immunopathol. 2011 Aug 15;142(3-4):179-88. doi: 10.1016/j.vetimm.2011.05.007. Epub 2011 May 7.
9
[Generation and evaluation of a recombinant myxomavirus expressing the VP60 protein of rabbit haemorrhagic disease virus].[表达兔出血症病毒VP60蛋白的重组黏液瘤病毒的构建与评价]
Sheng Wu Gong Cheng Xue Bao. 2020 Oct 25;36(10):2083-2091. doi: 10.13345/j.cjb.200111.
10
Construction and immunogenicity of novel bivalent virus-like particles bearing VP60 genes of classic RHDV(GI.1) and RHDV2(GI.2).新型二价病毒样颗粒的构建及其免疫原性，该颗粒携带经典 RHDV(GI.1)和 RHDV2(GI.2)的 VP60 基因。
Vet Microbiol. 2020 Jan;240:108529. doi: 10.1016/j.vetmic.2019.108529. Epub 2019 Nov 30.

引用本文的文献

1
Screening optimal DC-targeting peptide to enhance the immune efficacy of recombinant expressing RHDV VP60.筛选最佳的树突状细胞靶向肽以增强表达 RHDV VP60 的重组蛋白的免疫效力。
Virulence. 2024 Dec;15(1):2368080. doi: 10.1080/21505594.2024.2368080. Epub 2024 Jun 20.
2
Chimeric VLPs Bearing VP60 from Two Serotypes of Are Protective against Both Viruses.携带来自两种血清型轮状病毒VP60的嵌合病毒样颗粒对两种病毒均具有保护作用。
Vaccines (Basel). 2021 Sep 9;9(9):1005. doi: 10.3390/vaccines9091005.
3
Immunity against and the Impact of the Immunological Studies on Vaccination.免疫与免疫学研究对疫苗接种的影响。
Vaccines (Basel). 2021 Mar 13;9(3):255. doi: 10.3390/vaccines9030255.
4
Strict Assembly Restriction of Peptides from Rabbit Hemorrhagic Disease Virus Presented by Rabbit Major Histocompatibility Complex Class I Molecule RLA-A1.兔出血症病毒肽由兔主要组织相容性复合体 I 类分子 RLA-A1 呈递的严格组装限制。
J Virol. 2020 Aug 17;94(17). doi: 10.1128/JVI.00396-20.
5
The evolution of poxvirus vaccines.痘病毒疫苗的演变
Viruses. 2015 Apr 7;7(4):1726-803. doi: 10.3390/v7041726.
6
Codon optimization of the rabbit hemorrhagic disease virus (RHDV) capsid gene leads to increased gene expression in Spodoptera frugiperda 9 (Sf9) cells.兔出血症病毒（RHDV）衣壳基因的密码子优化导致其在草地贪夜蛾9（Sf9）细胞中的基因表达增加。
J Vet Sci. 2013;14(4):441-7. doi: 10.4142/jvs.2013.14.4.441. Epub 2013 Jun 30.
7
Conformational and thermal stability improvements for the large-scale production of yeast-derived rabbit hemorrhagic disease virus-like particles as multipurpose vaccine.为了大规模生产酵母来源的兔出血症病毒样颗粒作为多用途疫苗，对其构象和热稳定性进行了改进。
PLoS One. 2013;8(2):e56417. doi: 10.1371/journal.pone.0056417. Epub 2013 Feb 27.
8
Rabbit haemorrhagic disease (RHD) and rabbit haemorrhagic disease virus (RHDV): a review.兔出血症（RHD）和兔出血症病毒（RHDV）：综述。
Vet Res. 2012 Feb 10;43(1):12. doi: 10.1186/1297-9716-43-12.
9
The current status and future directions of myxoma virus, a master in immune evasion.黏液瘤病毒：免疫逃避大师的现状与未来方向
Vet Res. 2011 Jun 9;42(1):76. doi: 10.1186/1297-9716-42-76.
10
Review of companion animal viral diseases and immunoprophylaxis.伴侣动物病毒性疾病与免疫预防综述
Vaccine. 2009 Jan 22;27(4):491-504. doi: 10.1016/j.vaccine.2008.11.027. Epub 2008 Nov 27.

本文引用的文献

1
Single capripoxvirus recombinant vaccine for the protection of cattle against rinderpest and lumpy skin disease.用于保护牛免受牛瘟和结节性皮肤病侵害的单株山羊痘病毒重组疫苗。
Vaccine. 1993;11(7):737-42. doi: 10.1016/0264-410x(93)90258-y.
2
Protection of goats against peste des petits ruminants with a vaccinia virus double recombinant expressing the F and H genes of rinderpest virus.用表达牛瘟病毒F和H基因的痘苗病毒双重组体保护山羊抵抗小反刍兽疫。
Vaccine. 1993;11(9):961-4. doi: 10.1016/0264-410x(93)90386-c.
3
Recombinant rabbit hemorrhagic disease virus capsid protein expressed in baculovirus self-assembles into viruslike particles and induces protection.在杆状病毒中表达的重组兔出血症病毒衣壳蛋白自组装成病毒样颗粒并诱导产生保护作用。
J Virol. 1994 Oct;68(10):6794-8. doi: 10.1128/JVI.68.10.6794-6798.1994.
4
Molecular cloning, sequencing and expression in Escherichia coli of the capsid protein gene from rabbit haemorrhagic disease virus (Spanish isolate AST/89).兔出血症病毒（西班牙分离株AST/89）衣壳蛋白基因在大肠杆菌中的分子克隆、测序及表达
J Gen Virol. 1994 Sep;75 ( Pt 9):2409-13. doi: 10.1099/0022-1317-75-9-2409.
5
Sequence and genomic organization of a rabbit hemorrhagic disease virus isolated from a wild rabbit.
Virus Genes. 1995 Jan;9(2):121-32. doi: 10.1007/BF01702655.
6
Construction and characterization of an infectious vaccinia virus recombinant that expresses the influenza hemagglutinin gene and induces resistance to influenza virus infection in hamsters.表达流感血凝素基因并诱导仓鼠对流感病毒感染产生抗性的传染性痘苗病毒重组体的构建与鉴定。
Proc Natl Acad Sci U S A. 1983 Dec;80(23):7155-9. doi: 10.1073/pnas.80.23.7155.
7
Expression of rabies virus glycoprotein from a recombinant vaccinia virus.重组痘苗病毒中狂犬病病毒糖蛋白的表达
Nature. 1984;312(5990):163-6. doi: 10.1038/312163a0.
8
Live recombinant vaccinia virus protects chimpanzees against hepatitis B.活重组痘苗病毒可保护黑猩猩免受乙型肝炎感染。
Nature. 1984;311(5981):67-9. doi: 10.1038/311067a0.
9
Construction of poxviruses as cloning vectors: insertion of the thymidine kinase gene from herpes simplex virus into the DNA of infectious vaccinia virus.痘病毒作为克隆载体的构建：将单纯疱疹病毒的胸苷激酶基因插入有感染性的痘苗病毒DNA中。
Proc Natl Acad Sci U S A. 1982 Aug;79(16):4927-31. doi: 10.1073/pnas.79.16.4927.
10
Protection from rabies by a vaccinia virus recombinant containing the rabies virus glycoprotein gene.含有狂犬病病毒糖蛋白基因的痘苗病毒重组体对狂犬病的防护作用。
Proc Natl Acad Sci U S A. 1984 Nov;81(22):7194-8. doi: 10.1073/pnas.81.22.7194.

用表达兔出血性疾病病毒衣壳蛋白的重组黏液瘤病毒预防黏液瘤病和兔病毒性出血病

Protection against myxomatosis and rabbit viral hemorrhagic disease with recombinant myxoma viruses expressing rabbit hemorrhagic disease virus capsid protein.

作者信息

Bertagnoli S, Gelfi J, Le Gall G, Boilletot E, Vautherot J F, Rasschaert D, Laurent S, Petit F, Boucraut-Baralon C, Milon A

机构信息

Laboratoire Associé de Microbiologie Moléculaire, Institut National de la Recherche Agronomique and Ecole Nationale Vétérinaire, Toulouse, France.

出版信息

J Virol. 1996 Aug;70(8):5061-6. doi: 10.1128/JVI.70.8.5061-5066.1996.

DOI:10.1128/JVI.70.8.5061-5066.1996
PMID:8764013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC190460/
Abstract

Two myxoma virus-rabbit hemorrhagic disease virus (RHDV) recombinant viruses were constructed with the SG33 strain of myxoma virus to protect rabbits against myxomatosis and rabbit viral hemorrhagic disease. These recombinant viruses expressed the RHDV capsid protein (VP60). The recombinant protein, which is 60 kDa in size, was antigenic, as revealed by its reaction in immunoprecipitation with antibodies raised against RHDV. Both recombinant viruses induced high levels of RHDV- and myxoma virus-specific antibodies in rabbits after immunization. Inoculations by the intradermal route protected animals against virulent RHDV and myxoma virus challenges.

摘要

构建了两种兔黏液瘤病毒 - 兔出血性疾病病毒（RHDV）重组病毒，其采用黏液瘤病毒的SG33株，以保护兔子免受黏液瘤病和兔病毒性出血性疾病的侵害。这些重组病毒表达RHDV衣壳蛋白（VP60）。该重组蛋白大小为60 kDa，具有抗原性，这通过其与针对RHDV产生的抗体在免疫沉淀反应中得到证实。两种重组病毒在免疫后均能在兔子体内诱导产生高水平的RHDV和黏液瘤病毒特异性抗体。通过皮内途径接种可保护动物免受强毒RHDV和黏液瘤病毒的攻击。