用表达兔出血性疾病病毒衣壳蛋白的重组黏液瘤病毒预防黏液瘤病和兔病毒性出血病
Protection against myxomatosis and rabbit viral hemorrhagic disease with recombinant myxoma viruses expressing rabbit hemorrhagic disease virus capsid protein.
作者信息
Bertagnoli S, Gelfi J, Le Gall G, Boilletot E, Vautherot J F, Rasschaert D, Laurent S, Petit F, Boucraut-Baralon C, Milon A
机构信息
Laboratoire Associé de Microbiologie Moléculaire, Institut National de la Recherche Agronomique and Ecole Nationale Vétérinaire, Toulouse, France.
出版信息
J Virol. 1996 Aug;70(8):5061-6. doi: 10.1128/JVI.70.8.5061-5066.1996.
Abstract
Two myxoma virus-rabbit hemorrhagic disease virus (RHDV) recombinant viruses were constructed with the SG33 strain of myxoma virus to protect rabbits against myxomatosis and rabbit viral hemorrhagic disease. These recombinant viruses expressed the RHDV capsid protein (VP60). The recombinant protein, which is 60 kDa in size, was antigenic, as revealed by its reaction in immunoprecipitation with antibodies raised against RHDV. Both recombinant viruses induced high levels of RHDV- and myxoma virus-specific antibodies in rabbits after immunization. Inoculations by the intradermal route protected animals against virulent RHDV and myxoma virus challenges.
摘要
构建了两种兔黏液瘤病毒 - 兔出血性疾病病毒（RHDV）重组病毒，其采用黏液瘤病毒的SG33株，以保护兔子免受黏液瘤病和兔病毒性出血性疾病的侵害。这些重组病毒表达RHDV衣壳蛋白（VP60）。该重组蛋白大小为60 kDa，具有抗原性，这通过其与针对RHDV产生的抗体在免疫沉淀反应中得到证实。两种重组病毒在免疫后均能在兔子体内诱导产生高水平的RHDV和黏液瘤病毒特异性抗体。通过皮内途径接种可保护动物免受强毒RHDV和黏液瘤病毒的攻击。
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