Finkelstein F O, Kliger A S, Bastl C, Yap P
Nephron. 1977;18(6):342-7. doi: 10.1159/000180853.
The long-term efficiency of chronic peritoneal dialysis was investigated during a 10-months follow-up period in eight patients with indwelling Tenckhoff catheters by determining sequential urea, creatine and glucose clearances. Dialysis was performed in the hospital with nurses changing commercially prepared 2-liter dialysate bottles. Mean +/- SE urea clearance declined from an initial valua of 23.6 +/- 1.5 ml/min to 17.7 +/- 1.2 at the termination of the study. The mean glucose and creatinine clearance also decreased from 14.1 +/- 0.9 to 10.2 +/- 0.7 and from 17.5 +/- 1.9 to 12.9 +/- 1.0, respectively. All of these decreases were statistically significant (p less than 0.05) by paired t testing analysis. It is concluded that the efficiency of chronic peritoneal dialysis may decline during maintenance therapy and that sequential clearance measurements should be obtained in all chronic peritoneal dialysis patients.
通过测定连续的尿素、肌酐和葡萄糖清除率，对8例留置Tenckhoff导管的患者在10个月的随访期内进行了慢性腹膜透析的长期效率研究。透析在医院进行，由护士更换市售的2升透析液瓶。平均±标准误尿素清除率从初始值23.6±1.5ml/分钟降至研究结束时的17.7±1.2。平均葡萄糖和肌酐清除率也分别从14.1±0.9降至10.2±0.7，从17.5±1.9降至12.9±1.0。通过配对t检验分析，所有这些下降均具有统计学意义（p<0.05）。得出的结论是，慢性腹膜透析的效率在维持治疗期间可能会下降，并且所有慢性腹膜透析患者均应进行连续清除率测量。
