Hartman P, Goldstein P, Algarra M, Hubbard D, Mabery J
Department of Biology, Texas Christian University, Fort Worth 76129, USA.
Mutat Res. 1996 Aug 8;363(3):201-8. doi: 10.1016/0921-8777(96)00012-2.
Survival after gamma irradiation (generated from either a 137Cs or 60Co source) was determined for two strains of the nematode Caenorhabditis elegans. Animals were between 1.3 and 39 times more sensitive to cesium than to cobalt. The magnitude of this differential sensitivity was dependent upon the strain, developmental stage and sex tested. Several control experiments eliminated trivial explanations for this difference. Since cobalt- and cesium-generated gamma particles have nearly identical energy depositions, the differential sensitivity likely reflects different mechanisms of processing the slightly different spectra of DNA damage induced by these two radiations. Sex-specific differences in radiation sensitivity were also noted and were likely due to the fact that males possess a single X chromosome rather than two, as do hermaphrodites.
测定了两种秀丽隐杆线虫品系在γ射线照射（由137Cs或60Co源产生）后的存活率。线虫对铯的敏感性比对钴的敏感性高1.3至39倍。这种差异敏感性的程度取决于所测试的品系、发育阶段和性别。几个对照实验排除了对这种差异的无关解释。由于钴和铯产生的γ粒子具有几乎相同的能量沉积，这种差异敏感性可能反映了处理这两种辐射诱导的略有不同的DNA损伤谱的不同机制。还注意到辐射敏感性存在性别特异性差异，这可能是因为雄性只有一条X染色体，而雌雄同体有两条。
