Peterec S M, Brennan S A, Rinder H M, Wnek J L, Beardsley D S
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA.
J Pediatr. 1996 Aug;129(2):269-74. doi: 10.1016/s0022-3476(96)70253-6.
Reticulated platelets (RPs) are newly synthesized platelets with increased ribonucleic acid content. The percentage of RPs is elevated in adults with thrombocytopenia as a result of increased platelet destruction. The objectives of this study were to determine normal RP values in neonates at birth and to determine whether neonates with thrombocytopenia as a result of increased platelet destruction have an increased percentage of RPs.
The RP percentages were measured at birth in 89 neonates without thrombocytopenia in three gestational age groups (<30,30 to 36, and >36 weeks), six neonates with immune thrombocytopenia, and one neonate with thrombocytopenia as a result of decreased platelet production.
The RP percentages in neonates without thrombocytopenia >36 weeks and 30 to 36 weeks of gestation were 4.0% +/- 2.4% (mean +/- SD) and 4.6% +/- 1.7%, respectively, similar to values reported in healthy adults. Neonates younger than 30 weeks of gestation had significantly higher RP percentages (8.8% +/- 5.1%) than older neonates (p </= 0.0001). Term neonates with immune thrombocytopenia had significantly higher RP percentages (38.3% +/- 23.1%) than term neonates without thrombocytopenia (p = 0.0001), with no overlap in RP values. A lower RP percentage (1.5%) and significantly lower absolute RP count were measured in the one neonate with decreased platelet production.
These preliminary data establish normal RP percentages in term and preterm neonates at birth and demonstrate elevated RP percentages in neonates with immune platelet destruction. The RP values may be helpful in evaluating the causes of neonatal thrombocytopenia.
网织血小板（RPs）是新合成的、核糖核酸含量增加的血小板。在因血小板破坏增加导致血小板减少的成人中，RPs的百分比会升高。本研究的目的是确定新生儿出生时RPs的正常数值，并确定因血小板破坏增加而出现血小板减少的新生儿其RPs百分比是否升高。
测量了三个胎龄组（<30周、30至36周、>36周）的89名无血小板减少的新生儿、6名免疫性血小板减少的新生儿以及1名因血小板生成减少导致血小板减少的新生儿出生时的RPs百分比。
胎龄>36周和30至36周的无血小板减少新生儿的RPs百分比分别为4.0%±2.4%（平均值±标准差）和4.6%±1.7%，与健康成人报告的值相似。胎龄小于30周的新生儿的RPs百分比（8.8%±5.1%）显著高于较大的新生儿（p≤0.0001）。足月免疫性血小板减少的新生儿的RPs百分比（38.3%±23.1%）显著高于足月无血小板减少的新生儿（p = 0.0001），RPs数值无重叠。在那名因血小板生成减少的新生儿中，测量到较低的RPs百分比（1.5%）和显著较低的绝对RPs计数。
这些初步数据确定了足月和早产新生儿出生时RPs的正常百分比，并证明了免疫性血小板破坏的新生儿中RPs百分比升高。RPs数值可能有助于评估新生儿血小板减少的原因。
