6-(2,5-二氯苯基)-2,4-二氨基-1,3,5-三嗪及相关合成化合物对大鼠结肠中氧化偶氮甲烷诱导的异常隐窝病灶的抑制作用
Suppressing effects of 6-(2,5-dichlorophenyl)-2,4-diamino-1,3,5-triazine and related synthetic compounds on azoxymethane-induced aberrant crypt foci in rat colon.
作者信息
Hirose Y, Tanaka T, Makita H, Yang M, Satoh K, Hara A, Maeda M, Toriyama H B, Mori H, Tsuda H
机构信息
First Department of Pathology, Gifu University School of Medicine, Japan.
出版信息
Jpn J Cancer Res. 1996 Jun;87(6):549-54. doi: 10.1111/j.1349-7006.1996.tb00258.x.
The modifying effects of dietary administration of 6-(2,5-dichlorophenyl)-2,4-diamino-1,3,5-triazine and 5 related compounds on the occurrence of azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) were investigated in rats. Male F344 rats were given s.c. injections of AOM (15 mg/kg body weight) once a week for 3 weeks to induce ACF. They also received the diet containing 200 ppm test compound for 5 weeks, starting one week before the first dosing of AOM. At the termination of experiment, all of the compounds had caused a significant reduction in ACF frequency, which might be associated with suppression of the expression of proliferation biomarkers. The apoptotic index in the colonic mucosal epithelium of rats killed at 6 h after the first AOM exposure revealed no blocking activity of the compounds.
研究了在大鼠中，饮食给予6-(2,5-二氯苯基)-2,4-二氨基-1,3,5-三嗪及5种相关化合物对偶氮甲烷(AOM)诱导的结肠异常隐窝灶(ACF)发生的修饰作用。雄性F344大鼠每周皮下注射一次AOM(15 mg/kg体重)，共3周以诱导ACF。从首次给予AOM前一周开始，它们还接受含200 ppm受试化合物的饮食，持续5周。实验结束时，所有化合物均使ACF频率显著降低，这可能与增殖生物标志物表达的抑制有关。首次暴露于AOM后6小时处死的大鼠结肠黏膜上皮细胞凋亡指数显示，这些化合物无阻断活性。
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