伊索格拉定是一种有效的血管生成抑制剂。
Irsogladine is a potent inhibitor of angiogenesis.
作者信息
Sato Y, Morimoto A, Kiue A, Okamura K, Hamanaka R, Kohno K, Kuwano M, Sakata T
机构信息
Department of Internal Medicine 1, Oita Medical University, Japan.
出版信息
FEBS Lett. 1993 May 10;322(2):155-8. doi: 10.1016/0014-5793(93)81558-h.
We describe a novel inhibitor of angiogenesis, Irsogladine, an anti-ulcer drug. Irsogladine inhibited plasminogen activator synthesis of, and tube formation by, human microvascular endothelial cells in type 1 collagen gel treated with an angiogenic growth factor, EGF. Furthermore, Irsogladine administered orally significantly inhibited in vivo angiogenesis in mice. Irsogladine may be useful in the treatment of diseases associated with angiogenesis.
我们描述了一种新型血管生成抑制剂——伊索格拉定，一种抗溃疡药物。伊索格拉定抑制了在经血管生成生长因子表皮生长因子（EGF）处理的I型胶原凝胶中培养的人微血管内皮细胞的纤溶酶原激活物合成及管腔形成。此外，口服伊索格拉定能显著抑制小鼠体内的血管生成。伊索格拉定可能对治疗与血管生成相关的疾病有用。
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