亚洲野生小鼠中一种新型内源性小鼠乳腺肿瘤病毒基因座及其进化分歧。

A novel endogenous mouse mammary tumor virus locus in Asian wild mice and its evolutionary divergency.

作者信息

Naruse M, Tsukada M, Koizumi A

机构信息

Department of Hygiene, Akita University School of Medicine, Japan.

出版信息

Zoolog Sci. 1996 Apr;13(2):299-302. doi: 10.2108/zsj.13.299.

DOI:10.2108/zsj.13.299

PMID:8766928

Abstract

The divergency of endogenous mouse mammary tumor virus (MMTV) in European mouse strains indicates acquisition of exogenous MMTV into their genomes during evolution. In the present study, we selected two strains of Asian wild mice, Cas-Hmi (Mus musculus castaneus) and Sub-Kjr (M. m. subspecies) to investigate a possible divergency of endogenous MMTVs among Asian mouse strains. Southern blot analysis and polymerase chain reaction (PCR) demonstrated that Cas-Hmi and Sub-Kjr have the full structure of integrated endogenous MMTVs, suggesting that these mice were diverged during evolution after MMTV endemics.

摘要

欧洲小鼠品系中内源性小鼠乳腺肿瘤病毒（MMTV）的差异表明，在进化过程中其基因组获得了外源性MMTV。在本研究中，我们选择了两种亚洲野生小鼠品系，即卡斯-希米（小家鼠栗色亚种）和苏布-基尔（小家鼠亚种），以研究亚洲小鼠品系中内源性MMTVs可能存在的差异。Southern印迹分析和聚合酶链反应（PCR）表明，卡斯-希米和苏布-基尔具有整合的内源性MMTVs的完整结构，这表明这些小鼠在MMTV地方病流行后在进化过程中发生了分化。